Monitoring of Effectiveness of Prostaglandin Therapy in Humans
Since the discovery of prostaglandin I2 (PGI2) in 1976 and the reports that this endogenously produced substance is diminished in atherosclerosis, it has been widely used together with PGE1 for the treatment of human atherosclerosis. Most of the therapeutic regimes were based upon Szczeklik’s report  stating that a 72-h continuous intra-arterial infusion results in a clinical benefit in patients suffering from peripheral vascular disease. Owing to the preliminary success prostaglandins were handled with exaggerated enthusiasm without any search for a better therapeutic scheme or for methods allowing the verification of the effect of therapeutic intervention.
KeywordsPlatelet Deposition Human Atherosclerotic Lesion Autologous Platelet Citrate Dextrose Arteriosclerosis Obliterans
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