Abstract
The vascular endothelium and, especially, the pulmonary endothelium play the important metabolic role in activation (e.g., angiotensin I) and inactivation (e.g., bradykinin, 5-hydroxytryptamine, catecholamines, nucleotides) of circulating hormones and autacoids [120]. Apart from its metabolic function the endothelium also acts as a generator of two powerful mediators: prostacyclin [34, 84] and endothelium-derived relaxing factor (EDRF) [29]. In contrast with “classical” mediators prostacyclin (t 1/2 = approx 4 min) [12, 34] and EDRF (t 1/2 = approx 6 s) [16, 32] are highly labile. Prostacyclin is one of the products of cyclo-oxygenation of arachidonic acid, while the chemical structure of EDRF remains unknown. Both these mediators are released from the endothelium by similar stimuli, including agonists of muscarinic and serotonin receptors, thrombin, bradykinin and calcium ionophore A 23 187 [36]. Lipid peroxides and oxygen free radicals are the decisive factors in either suppression of the generation or termination of the action of these mediators [34, 37, 121].
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Gryglewski, R.J. (1987). The Impact of Prostacyclin Studies on the Development of Its Stable Analogues. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_1
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