Multiwavelength Anomalous Diffraction in Protein Crystallography: Phase Calculations, Experimental Procedures and Results

  • R. Fourme
  • M. Chiadmi
  • R. Kahn
Conference paper
Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 2)


Once suitable crystals have been grown, the phase problem- i. e. the determination of structure factor phases from Bragg reflection intensity data — remains the crucial difficulty of the ab-initio elucidation of any three-dimensional macromolecular structure by X-ray diffraction methods. The techniques which have been most commonly used to circumvent this problem have involved the special diffraction characteristics associated with the presence of a small number of heavy atoms which are either naturally present or purposely introduced in the parent structure of interest.


Heavy Atom Bragg Reflection Joint Probability Distribution Acta Cryst Anomalous Dispersion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • R. Fourme
    • 1
  • M. Chiadmi
    • 1
  • R. Kahn
    • 1
  1. 1.LURE (CNRS, MEN & CEA) Université de Paris-SudOrsay CedexFrance

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