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Diuretics and Magnesium Handling

  • Conference paper
Book cover Diuretika III

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Abstract

A discussion of diuretic action on magnesium excretion is usually preceded by a short review of overall homeostasis and renal handling of magnesium. Magnesium is the fourth most abundant cation in the human body and the second most common cation in the intracellular fluid next to potassium. The adult human body contains 21–28 g of magnesium [1]. The plasma magnesium concentration ranges from 0.7 to 1.0 mmol/liter in normal subjects. Approximately 2% of the total body magnesium is located in extracellular compartments. The major magnesium pool is almost exclusively intracellular; approximately 65% is found in the bone, 20% in the muscle and 11% in the nonmuscle soft tissue. Intracellular magnesium plays a vital role in many cell processes, including production and utilization of energy as the membrane bound Mg-activated adenosine triphosphatase [2, 3]. Extracellular magnesium is implicated in neuronal control, neuromuscular transmission and cardiovascular tone [4]. In man, approximately 30%–40% of dietary absorption takes place in the small intestine, less in the duodenum than in the ileum [5].

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Authors
  1. J. H. Dirks
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  2. N. L. M. Wong
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Editors and Affiliations

  1. Medizinische Universitäts-Poliklinik Bonn, Wilhelmstraße 35-37, D-5300, Bonn, Germany

    F. Krück

  2. 42 rue du X Octobre, L-7243, Béreldange, Germany

    A. Schrey

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© 1986 Springer-Verlag Berlin Heidelberg

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Dirks, J.H., Wong, N.L.M. (1986). Diuretics and Magnesium Handling. In: Krück, F., Schrey, A. (eds) Diuretika III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71487-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-71487-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71489-4

  • Online ISBN: 978-3-642-71487-0

  • eBook Packages: Springer Book Archive

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