Effects of a Single Oral Dose of Milrinone on Left Ventricular Systolic Performance
The introduction of the cardiac bipyridines into the pharmacotherapy of congestive heart failure marked the beginning of innovative research in this area of cardiovascular pharmacology [1, 5, 6]. The forerunner of this new group of compounds was amrinone, which has been proved effective both intravenously  and orally  in treating congestive heart failure. The limitation of this drug is the high incidence, after long-term oral therapy, of gastrointestinal side effects, thrombocytopenia, and fever [11, 18].
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