The Reaction of Hemocyanin from Octopus Vulgaris with Nitrite. A Reinterpretation of the Oxidation Pathways
The reaction of Hemocyanin with nitric oxide has been observed since a long time (1). An interpretation in terms of redox reaction was first proposed by Schoot Uiterkamp (2) and Schoot Uiterkamp and Mason (3). Different chemical schemes have been reported since then to explain this reaction. In all cases NO was assumed to be the oxidant, whereas different interpretation were advanced about the nature and state of ligation of the oxidation product (4,5,6). According to a recent review by Solomon (7), the generally accepted chemistry of oxidation of molluscan hemocyanin involves the oxidation of the deoxy form by NO to an half-met-NO 2 − intermediate which can be further oxidized to a “dimer” (i.e. an EPR detectable met) in the form of a [Cu(II) CU(II)]NxOy derivative.
KeywordsSuperoxide Nitrite Quinone Catechol Univer
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