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Interconnectedness of Steroid Hormone-Binding Neurons: Existence and Implications

  • Conference paper
Morphology of Hypothalamus and Its Connections

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 7))

Abstract

Neurons in the central nervous system concentrate estrogen, progesterone, testosterone or dihydrotestosterone, and corticosterone. The location of these neurons in the brain has been determined by using autoradiographic (Pfaff 1968; Pfaff and Keiner 1973; Stumpf et al. 1975; Morrell and Pfaff 1981) and steroid receptorbinding techniques (McEwen et al. 1979). Steroid sex hormone-binding cells are found in the medial preoptic area, medial hypothalamus, and limbic forebrain areas in the vertebrate brain; in general, these neurons are found in brain regions that participate in behavioral and pituitary reproductive functions (McEwen et al. 1979). In contrast corticosterone-concentrating neurons are found primarily in the hippocampus.

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  1. Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY, 10021-6399, USA

    S. L. Cottingham & D. Pfaff

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  1. S. L. Cottingham
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  2. D. Pfaff
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  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 6900, Heidelberg, Germany

    Detlev Ganten M.D., Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, NY, 10021, USA

    Donald Pfaff Ph.D.

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Cottingham, S.L., Pfaff, D. (1986). Interconnectedness of Steroid Hormone-Binding Neurons: Existence and Implications. In: Ganten, D., Pfaff, D. (eds) Morphology of Hypothalamus and Its Connections. Current Topics in Neuroendocrinology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71461-0_7

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