Interconnectedness of Steroid Hormone-Binding Neurons: Existence and Implications

  • S. L. Cottingham
  • D. Pfaff
Part of the Current Topics in Neuroendocrinology book series (CT NEUROENDOCRI, volume 7)


Neurons in the central nervous system concentrate estrogen, progesterone, testosterone or dihydrotestosterone, and corticosterone. The location of these neurons in the brain has been determined by using autoradiographic (Pfaff 1968; Pfaff and Keiner 1973; Stumpf et al. 1975; Morrell and Pfaff 1981) and steroid receptorbinding techniques (McEwen et al. 1979). Steroid sex hormone-binding cells are found in the medial preoptic area, medial hypothalamus, and limbic forebrain areas in the vertebrate brain; in general, these neurons are found in brain regions that participate in behavioral and pituitary reproductive functions (McEwen et al. 1979). In contrast corticosterone-concentrating neurons are found primarily in the hippocampus.


Ventral Tegmental Area Lateral Septum Lateral Hypothalamic Area Stria Terminalis Medial Preoptic Area 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. L. Cottingham
    • 1
  • D. Pfaff
    • 1
  1. 1.Laboratory of Neurobiology and BehaviorThe Rockefeller UniversityNew YorkUSA

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