Abstract
The earliest electron microscopic studies of gonadotropes were reported by Farquhar and Rinehart in 1954. The design of their study followed that of pioneering light microscopic studies of the previous 3 decades, which showed distinct changes in each pituitary cell type after removal of its respective target organ. These studies had allowed the identification of most of the pituitary cells by linking their affinity for unique tinctorial stains with striking cytologic changes observed upon alteration of target organ hormonal feedback (Purves and Griesbach 1954). In the case of the gonadotrope, it was already known that the removal of the gonads caused the cells to enlarge dramatically and become filled with vacuoles or one large vacuole, giving them the appearance of “swiss cheese,” or “signet rings.”
The research described in this review was supported by National Foundation March of Dimes Basil O’Connor and Basic Research Grants 1–551, and by NIH grants RO1 HD00842 (University of Nebraska), ROI HD10930 (Northwestern University) and RO1 HD15472 (University of Texas Medical Branch). Dr. Childs was supported by RCDA 1 K04 HD AM-00306 (Northwestern) and HD00395 (UTMB) between 1979 and 1984
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Childs, G.V. (1986). Functional Ultrastructure of Gonadotropes: a Review. In: Ganten, D., Pfaff, D. (eds) Morphology of Hypothalamus and Its Connections. Current Topics in Neuroendocrinology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71461-0_2
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