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Frequency Regulation in the Sinoatrial Node: Function of β1- and β2-Receptors

  • U. Borchard
  • D. Hafner
  • D. Schütz
Conference paper

Abstract

Since the subclassification of β-adrenoceptors by Lands et al. [13], the coexistence of β 1- and β 2-adrenoceptors has been shown in different organs [1, 8]. β 1- and β 2-adrenoceptors have been identified in the ventricular myocardium by means of binding experiments as well as concentration-response curves for the positive inotropic action of ß-agonists in the absence and presence of partially selective antagonists [4, 7, 10, 11, 14].

Keywords

Beat Frequency Sinoatrial Node Spontaneous Rate Positive Chronotropic Effect Schild Plot 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ariens EJ, Simonis AM (1983) Physiological and pharmacological aspects of adrenergic receptor classification. Biochem Pharmacol 32 (10): 1539–1545Google Scholar
  2. 2.
    Brodde OE, Leifert FJ, Krehl HJ (1982) Coexistence of β1 and β2-adrenoceptors in the rabbit heart: quantitative analysis of the regional distribution by (-)- 3H dihydroalprenolol binding. J Cardiovasc Pharmacol 4: 34–43Google Scholar
  3. 3.
    Bryan LJ, Cole JJ, O’Donnell SR, Wanstall JC (1981) A study designed to explore the hypothesis that beta-1 adrenoceptors are innervated receptors and beta-2 adrenoceptors are hormonal receptors. J Pharmacol Exp Ther 216: 395–400Google Scholar
  4. 4.
    Dukes ID, Vaughan Williams EM (1984) Effects of selective α1, α2, β1 and β2-adrenoceptor stimulation on potentials and contractions in the rabbit heart. J Physiol (Lond) 355: 523–546Google Scholar
  5. 5.
    Goldie RG, Paterson JW, Spina D, Wale JL (1984) Classification of ß-adrenoceptors in human isolated bronchus. Br J Pharmacol 81: 611–615Google Scholar
  6. 6.
    Hedberg A, Minnemann KP, Molinoff PB (1980) Differential distribution of beta-1 and beta-2 adrenergic receptors in cat and guinea-pig heart. J Pharmacol Exp Ther 212: 503–508Google Scholar
  7. 7.
    Heitz A, Schwartz J, Velly J (1983) β-adrenoceptors of the human myocardium: determination of β 1 and β 2 subtypes by radioligand binding. Br J Pharmacol 80: 711–717Google Scholar
  8. 8.
    Hoffman BB, Lefkowitz RJ (1980) Radioligand binding studies of adrenergic receptors: new in-sights into molecular and physiological regulation. Ann Rev Pharmacol Toxicol 20: 581–608Google Scholar
  9. 9.
    Johansson LH, Persson H (1983) β-adrenoceptors in guinea-pig atria. J Pharm Pharmacol 35: 804 - 807Google Scholar
  10. 10.
    Kaumann AJ (1983) Herz- β-Rezeptoren - experimentelle Standpunkte. Z Kardiol 72: 63–82Google Scholar
  11. 11.
    Kaumann AJ, Lemoine H (1985) Direct labelling of myocardial β1-adrenoceptors. Naunyn- Schmiedebergs Arch Pharmacol 331: 27–29Google Scholar
  12. 12.
    Kaumann AJ, Marano M (1982) On equilibrium dissociation constants for complexes of drug- receptor subtypes. Naunyn-Schmiedebergs Arch Pharmacol 318:192–201Google Scholar
  13. 13.
    Lands AM, Arnold A, McAucliff JP, Luduena FP, Brown TG (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214: 597 - 598PubMedCrossRefGoogle Scholar
  14. 14.
    Minnemann KP, Hegstrand LR, Molinoff PB (1979) Simultaneous determination of beta-1 and beta-2 adrenergic receptors in tissues containing both receptor subtypes. Mol Pharmacol 16: 34–46Google Scholar
  15. 15.
    O’Donnell SR, Wanstall JC (1979) pA2-values of selective β-adrenoceptor antagonists on isolated atria demonstrate a species difference in the β-adrenoceptor populations mediating chronotropic responses in cat and guinea-pig. J Pharm Pharmacol 31: 686–690Google Scholar
  16. 16.
    O’Donnell SR, Wanstall JC (1979) The importance of choice of agonist in studies designed to predict β2- β 1 adrenoceptor selectivity of antagonists from pA2-values on guinea-pig trachea and atria. Naunyn-Schmiedebergs Arch Pharmacol 308:183–190Google Scholar
  17. 17.
    O’Donnell SR, Wanstall JC (1980) Evidence that ICI 118551 is a potent, highly beta2-selective adrenoceptor antagonist and can be used to characterize beta-adrenoceptor populations in tissues. Life Sci 27: 671–677Google Scholar
  18. 18.
    Takayangi I, Kondo N, Yamashita H, Hongo T, Takagi K (1977) New selective β 2-adrenoceptor stimulants 5-(l-hydroxy-2-ethylaminobutyl)-8-hydroxycarbostyril hydrochlorides (OPC-2009 and OPC-2030) and cyclic AMP concentration. J Pharm Pharmacol 29:187–189Google Scholar
  19. 19.
    Yamashita S, Takai M, Yabundi Y (1978) Actions of procaterol (OPC-2009), a new β2-adrenoceptor stimulant, on pulmonary resistance, contractions of the soleus muscle, and cardiovascular system of the anaesthetized cat. J Pharm Pharmacol 30: 273–279Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • U. Borchard
    • 1
  • D. Hafner
    • 1
  • D. Schütz
    • 1
  1. 1.Institut für Pharmakologie der Universität DüsseldorfDüsseldorf 1Federal Republic of Germany

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