Frequency Regulation in the Sinoatrial Node: Function of β1- and β2-Receptors

  • U. Borchard
  • D. Hafner
  • D. Schütz
Conference paper


Since the subclassification of β-adrenoceptors by Lands et al. [13], the coexistence of β 1- and β 2-adrenoceptors has been shown in different organs [1, 8]. β 1- and β 2-adrenoceptors have been identified in the ventricular myocardium by means of binding experiments as well as concentration-response curves for the positive inotropic action of ß-agonists in the absence and presence of partially selective antagonists [4, 7, 10, 11, 14].


Beat Frequency Sinoatrial Node Spontaneous Rate Positive Chronotropic Effect Schild Plot 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • U. Borchard
    • 1
  • D. Hafner
    • 1
  • D. Schütz
    • 1
  1. 1.Institut für Pharmakologie der Universität DüsseldorfDüsseldorf 1Federal Republic of Germany

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