Characterization of Adrenoceptors: Receptor-Binding Studies and Agonist-Antagonist Interaction

  • A. Wellstein
Conference paper


In the last decade receptor-binding studies have received ever increasing attention. Especially in adrenergic pharmacology, they have proved to be very powerful and reliable tools in many respects, as outlined in the different articles of the present volume and in the literature [2, 7, 11,12, 17, 20]. However, it must be pointed out that despite such numerous reports, there are still some contradictions and especially confusion about when acceptable proof has been obtained that a radioligand under investigation has indeed bound at receptors [8,20]. In the present paper, we discuss aspects and prerequisites of the receptor binding approach and how this could provide a better understanding of the action of the classical β-adrenoceptor antagonist, propranolol.


Hill Slope Equilibrium Dissociation Constant Receptor Binding Study Exercise Tachycardia Spare Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • A. Wellstein
    • 1
  1. 1.Zentrum der PharmakologieKlinikum der J. W. Goethe-UniversitätFrankfurt 70Federal Republic of Germany

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