Effect of Fludrocortisone on Adrenoceptors and Free Intracellular Calcium in Man

  • E. Fritschka
  • A. Kribben
  • S. Harwig
  • H. Haller
  • T. Lenz
  • H. M. Thiede
  • M. Luedersdorf
  • Th. Philipp
  • A. Distler


The mineralocorticoid - induced blood pressure increase in normotensive man is characterized by an early rise in cardiac output during the 1st week of steroid administration and a persistent increase in total peripheral resistance (TPR), which is observed later on, when cardiac output returns to pretreatment values [1,2]. The initial rise in cardiac output has been linked to sodium and volume retention [3,4]. The mechanism of the persistent increase in TPR in the presence of a normal or subnormal cardiac output remains elusive. Alterations of sympathetic nervous system activity and increased passive membrane permeability for sodium have been observed in animal models of mineralocorticoid hypertension [5, 6]. The present study examined parameters of sympathetic activity and intracellular calcium concentration, which ultimately should be linked to altered cellular sodium transport [7] in normotensive volunteers, in whom a mineralocorticoid-induced blood pressure increase was evoked by oral administration of fludrocortisone.


Mean Arterial Pressure Receptor Density Total Peripheral Resistance Intracellular Calcium Concentration Free Intracellular Calcium 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • E. Fritschka
    • 1
  • A. Kribben
    • 1
  • S. Harwig
    • 1
  • H. Haller
    • 1
  • T. Lenz
    • 1
  • H. M. Thiede
    • 1
  • M. Luedersdorf
    • 1
  • Th. Philipp
  • A. Distler
    • 1
  1. 1.Medizinische Klinik und Poliklinik, Klinikum SteglitzFreie Universität BerlinBerlin 45Federal Republic of Germany

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