Abstract
During the last decade, radioligand binding studies have greatly advanced our knowledge of the molecular pharmacology of β-adrenoceptors. With this technique, it has become increasingly apparent that the tissue concentration of β-adrenoceptors is not a fixed number but is rather dynamically regulated by a variety of drugs, hormones, pathological and physiological conditions [14,16,19, 20, 24]. In vitro and in vivo studies have shown that in numerous tissues, long-term exposure to β-adrenergic agonists results in an impaired β-adrenergic function. This reduced responsiveness of β-adrenoceptors was consistently found to be due to decreased receptor density and/or to a diminished activity of the adenylate cyclase-cAMP system.
This work was supported by the Landesamt für Forschung Nordrhein- Westfalen and the SANDOZ Stiftung für Therapeutische Forschung.
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Brodde, OE. (1986). Beta Adrenoceptor Changes in Hypertension Induced by Dynamic Exercise. In: Middeke, M., Holzgreve, H. (eds) New Aspects in Hypertension Adrenoceptors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71418-4_13
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