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Adrenoceptors in Hypertension

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New Aspects in Hypertension Adrenoceptors

Abstract

Hypertension is characterized by several hemodynamic abnormalities, such as an increase in cardiac output and an enhanced peripheral resistance. In the sustained hypertensive state, the increase in total peripheral resistance is predominant (Fig. 1). Peripheral resistance is modulated mainly by α- and β-adrenoceptors located at the sympathetic nerve terminal (presynaptic) and at the arteriolar vascular smooth muscle (postsynaptic). While much information is available about peripheral adrenergic mechanisms, the role of central nervous adrenergic mechanisms in developing and maintaining hypertension is poorly understood. Much attention has been focused on the presynaptic β 2-adrenoceptor and its role in facilitating neurotransmitter release and vasoconstriction in recent years [3,18,21,22]. By using radioligand binding studies to characterize and quantify adrenoceptors, we hope to increase our understanding of the role of sympathico-adrenergic system in the pathogenesis of hypertension and how it may be altered during antihypertensive therapy.

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Authors and Affiliations

  1. Medizinische Poliklinik der Ludwig-Maximilians-Universität, Pettenkoferstraße 8 a, 8000, München 2, Federal Republic of Germany

    M. Middeke

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  1. Medizinische Poliklinik der Ludwig-Maximilians-Universität München, Pettenkoferstr. 8 a, 8000, München 2, Federal Republic of Germany

    Martin Middeke  & Heinrich Holzgreve  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Middeke, M. (1986). Adrenoceptors in Hypertension. In: Middeke, M., Holzgreve, H. (eds) New Aspects in Hypertension Adrenoceptors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71418-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-71418-4_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71420-7

  • Online ISBN: 978-3-642-71418-4

  • eBook Packages: Springer Book Archive

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