Skip to main content
SpringerLink
Log in
Book cover

Fibrin Sealant in Operative Medicine pp 51–59Cite as

Preliminary Results of a Randomized Controlled Study on the Risk of Hepatitis Transmission of a Two-Component Fibrin Sealant (Tissucol/Tisseel)

  • Conference paper

Abstract

A hundred patients who were to undergo cerclage or conization were entered into the study, being assigned to either group A or B on a random basis, irrespective of the type of surgery planned. Group A received conventional surgery plus two-component fibrin sealant, group B received conventional surgery alone.

The objectives of the study were to demonstrate the efficacy of fibrin sealant as a sealing adjunct in cerclage and as an aid to wound healing in conization. A further objective was to evaluate the risk of hepatitis B and hepatitis non-A/non-B transmission through fibrin sealant. Efficacy results are published elsewhere; here data are presented only on the risk of viral hepatitis transmission.

Of the 100 patients who had entered the study, 69 had a sufficient number of blood samples taken to qualify for evaluation of the hepatitis risk (group A: n = 31; group B: n = 38). None of the patients in either group contracted hepatitis B or non-A/non-B.

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Seelich T, Redl H: Theoretische Grundlagen des Fibrinklebers. In: Fibrinogen, Fibrin und Fibrinkleber, ed. Schimpf K FK Schattauer Verlag, Stuttgart–New York, p. 199–208, 1980

    Google Scholar 

  2. Alter HJ, Purcell RH, Holland PV, Ailing DW, Koziol DE: Donor transaminase and recipient hepatitis. Impact on blood transfusion services. Jama, 246: 6, p. 630–634, 1981

    Article  PubMed  CAS  Google Scholar 

  3. Hornbrook MC, Dodd RY, Jacobs P, Friedman LI, Sherman KE: Reducing the incidence of non-A, non-B post-transfusion hepatitis by testing donor blood for alanine aminotransferase. N Engl. J Med, 307: 21, 1315–1321, 1982

    Article  PubMed  CAS  Google Scholar 

  4. Aach RD, Szmuness W, Mosley JW, Hollinger FB, Kahn RA, Stevens CE, Edwards VM, Werch J: Serum alanine aminotransferase of donors in relation to the risk of non-A, non-B hepatitis in recipients. N Engl J Med, 304: 17, 989–1035, 1981

    Article  PubMed  CAS  Google Scholar 

  5. Empfehlungen der Deutschen Gesellschaft für Klinische Chemie. Z klin Chem u klin Biochem, 10, 182–192, 1972

    Google Scholar 

  6. Scheele J, Schricker K TH, Goy D, Lampe I, Panis R: Hepatitisrisiko der Fibrinklebung in der Allgemeinchirurgie. Med Welt, 32, 783–788, 1981

    PubMed  CAS  Google Scholar 

  7. Paris R, Scheele J: Hepatitisrisiko bei der Fibrinklebung in der HNO-Chirurgie. Laryng Rhinol Otol, 60, 367–368, 1981

    Article  Google Scholar 

  8. Synopsis der Leberkrankheiten. Editors: H Wallnöfer, E Schmidt und F W Schmidt. G Thieme Verlag, Stuttgart, 1974

    Google Scholar 

  9. Thefeld W, Hoffmeister H, Busch EW, Koller PU, Vollmar J Referenzwerte für die Bestimmungen der Transaminasen GOT und GPT sowie der alkalischen Phosphatase im Serum mit optimierten Standardmethoden. Dtsch med Wschr, 99, 343–351, 1974

    Article  PubMed  CAS  Google Scholar 

  10. Persijn JP and W van der Slik: A new method for the determination of gamma-glutamyltransferase in serum. J Clin Chem Clin Biochem, 14: 9, 421–427, 1976

    PubMed  CAS  Google Scholar 

  11. Wüst H: Laboruntersuchungen. Klinische Gastroenterologie in zwei Bänden. Edited by L. Demling. Volume I: Diagnostische Übersicht, Mundhöhle und Rachen, Speiseröhre, Magen, Darm. 2. Auflage. G Theme Verlag, Stuttgart - New York, 1984

    Google Scholar 

  12. Seagroatt V, Magrath DI, Ferguson M, Anderson SG, Schild GC, and CH Cameron: Preliminary evaluation of a collaborative study of the proposed British standard for hepatitis B surface antigen. Med Lab Sci, 38, p. 335–339, 1981

    PubMed  CAS  Google Scholar 

  13. Barker LF, Gerety RJ, Lorenz DE, Rastogi SC and EB Seligmann Jr.: Biological standardization in viral hepatitis. In: Viral hepatitis. Eds. Vyas GN, Cohne SN, and Schmid R. The Franklin Institute Press, Philadelphia, 1978

    Google Scholar 

  14. Seeff LB: Hepatitis in hemophilia: a brief review. In: Frontiers in liver disease. Eds. Berk PD, Chalmers TC. Thieme Verlag Stratton Inc., New York, p. 231–241, 1981

    Google Scholar 

  15. Hoofnagle JH: Hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). In: Virus and the liver. Proceedings of the 28th Falk Symposium on the Occasion of the 5th Int. Congress of Liver Diseases 1979, p. 27–37. Eds. Bianchi L, Gerok W, Sickinger K, Stalder GA

    Google Scholar 

  16. Tabor E, Aronson DL, Gerety RJ: Removal of hepatitis B-virus infectivity from factor IX complex by hepatitis B immunglobulin. Lancet II, p. 68–70, 1980

    Google Scholar 

  17. Gerety RJ and Aronson DL. Plasma derivatives and viral hepatitis Transfusion 22:5, p. 347–351, 1982

    Google Scholar 

  18. Yoshizawa H, Akahane Y, Itoh Y, Iwakiri S, Kitajima K, Morita M, Tanaka A, Nojiri T, Shimizu M, Miyakawa Y, and M Mayumi: Viruslike particles in a plasma fraction (fibrinogen) and in the circulation of apparently healthy blood donors capable of inducing non-A/non-B hepatitis in humans and chimpanzees. Gastroenterology 79, 512–520, 1980

    PubMed  CAS  Google Scholar 

  19. Jackson D, Tabor E, Gerety RJ: Acute non-A, non-B hepatitis: specific ultrastructural alterations in endoplasmic reticulum of infected hepatocytes. Lancet I, p. 1249–1250, 1979

    Google Scholar 

  20. Gudat F, Eder G, Eder C, Bianchi L, Stöcklin E, Krey G, Dürmüller U and HP Spichtin: Experimental non-A/non-B hepatitis in chimpanzees: light, electron and immune microscopical observations. Liver 3, p. 110–121, 1983

    PubMed  CAS  Google Scholar 

  21. Sacher M, Eder G, Baumgarten K and H Thaler: Vertikale Hepatitis B Transmission. Ergebnisse einer prospektiven Studie 1978 bis 1981. Wr klin Wschr, 95–13, p. 447–451, 1983

    Google Scholar 

  22. Woo D, Cummins M, Davies PA, Harvey DR, Hurley R and AP Waterson: Vertical transmission of hepatitis B surface antigen in carrier mothers in two West London hospitals. Arch Dis Childhood 54, p. 670–675, 1979

    Article  CAS  Google Scholar 

  23. Sherertz RJ, Spindel E and JH Hoofnagle: Antibody to hepatitis B surface antigen may not always indicate immunity to hepatitis B virus infection. N Engl. J Med, 309: 24, 1983

    Google Scholar 

  24. Brotman B and AM Prince: Occurrence of AUSAB test positivity unrelated to prior exposure to hepatitis B virus. J Inf Dis 150: 5, p. 714–720, 1984

    Article  CAS  Google Scholar 

  25. Dienstag JL: Non-A, Non-B hepatitis. II. Experimental transmission, putative virus agents and markers, and prevention. Gastroenterology 85, p. 743–568, 1983

    PubMed  CAS  Google Scholar 

  26. Seto B, Coleman WG jr, Iwarson S and RS Gerety: Detection of reverse transcriptase activity in association with the non-A/non-B hepatitis Agent(s). Lancet II, p. 941–943, 1984

    Google Scholar 

Download references

Authors
  1. G. Eder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Neumann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Cerwenka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Baumgarten
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ludwig-Boltzmann-Instiut für experimentelle Traumatologie, Donaueschingenstraße 13, A-1200, Vienna, Austria

    Günther Schlag  & Heinz Redl  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Eder, G., Neumann, M., Cerwenka, R., Baumgarten, K. (1986). Preliminary Results of a Randomized Controlled Study on the Risk of Hepatitis Transmission of a Two-Component Fibrin Sealant (Tissucol/Tisseel). In: Schlag, G., Redl, H. (eds) Fibrin Sealant in Operative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71391-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71391-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16828-7

  • Online ISBN: 978-3-642-71391-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation