Neurite Outgrowth Induced by Adhesive Proteins

  • Heikki Rauvala
  • Yrjö Mähönen
  • Jukkapekka Jousimaa
  • Jussi Merenmies
  • Dan Lindholm
  • Matti Vuento
Part of the NATO ASI Series book series (volume 2)


Outgrowth of neurites during development and regeneration in central and peripheral nervous systems involves mechanisms based on soluble neurite-promoting molecules, like the nerve growth factor (1) and other diffusible substances (2–6). Adhesion of neurons to other cells or to the surrounding extracellular matrix is also thought to play an important role in the outgrowth of neurites (7). Thus, specialized regions of the neurons identified as growth cones adhere to surfaces of other cells or to other extracellular surfaces, and these adhesions are thought to guide axonal growth (7).


Nerve Growth Factor Neuroblastoma Cell Neurite Outgrowth Neural Cell Adhesion Molecule Nonneuronal Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Heikki Rauvala
    • 1
  • Yrjö Mähönen
    • 1
  • Jukkapekka Jousimaa
    • 1
  • Jussi Merenmies
    • 1
  • Dan Lindholm
    • 1
  • Matti Vuento
    • 2
  1. 1.Department of Medical ChemistryUniversity of HelsinkiFinland
  2. 2.Department of BiochemistryUniversity of HelsinkiFinland

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