Developmentally Regulated Glial and Neuronal Antigens Detected by Monoclonal Antibodies
Cell interactions must play an essential role in the implementation of the genetic programme. Cell signals during ontogenesis could modulate and, in some cases, determine choices in the processes of cell multiplication, differentiation, maturation, migration, and establishment of connections. This implies that, at molecular levels, the expression of each genetically coded signal molecule, giver (effector) and receiver (receptor), is also modulated by the preceding and the following cell interaction. Thus, in many cases the presence of signal effectors and/or receptors in a given cell should be necessary only for the required time.
KeywordsMigration Tyrosine Glycol Electrophoresis Retina
Unable to display preview. Download preview PDF.
- 1).Altman, J. (1982). Morphological development of the rat cerebellum and some of its mechanisms. In: The cerebellum, new vistas. Exp. Brain Res. Supp., 6, 8–46.Google Scholar
- 6).Ghandour, M. S., Langley, O. K. and Clos, J. (1983). Immunohistochemical and biochemical approaches to the development of neuroglia in the CNS, with special reference to cerebellum. Int. J. Devi. Neurosci., 1, 4II–425.Google Scholar
- 8).Goodman, C. S., Bastiani, M. J., Doe, C. Q., duLAC, S., Helfand, S.L., Kuwada, J. Y. and Thomas, J. B. (1984). Cell recognition during neuronal development. Science, 225, 1271–1279.Google Scholar
- 16).Mckay, R., Raff, M. C. and Reichardt, L. F. (1981). Monoclonal antibodies to neural antigens. Cold Spring Harbor reports in the Neuroscience, Vol. 2.Google Scholar
- 18).Miller, R. H. and Raff, M. C. (1984). Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct. J. Neuroscience, 4, 585–592.Google Scholar
- 19).O’farrel, P. H. (1975). High resolution two-dimensional electrophoresis of proteins. J. biol. Chem., 250, 982–986.Google Scholar