Neuroendokrine Studien zur therapeutischen Wirkung von Antidepressiva und Neuroleptika — Das Konzept der entaktivierenden Wirkung

  • G. Schönbeck
  • G. Langer
  • H. Aschauer
  • G. Koinig
  • F. Resch
Conference paper

Zusammenfassung

Seit der Entdeckung der Neuroleptika (Chlorpromazin; Delay et al. [4]) und Antidepressiva (Imipramin; Kuhn [9]) werden diese Pharmaka weltweit — wenn auch nicht immer erfolgreich — in der psychiatrischen Therapie angewendet. Viele Analogpräparate der „Originale“ sind seither synthetisch hergestellt worden, z. T. mit vergleichbarem psychopharmakologischem Profil. Obwohl heute die allgemeine Wirksamkeit dieser Medikamente erwiesen ist, bleibt ungeklärt, warum trotz adäquater Indikation und Therapie einige Patienten therapieresistent sind.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Carlsson A (1978) Mechanism of action of neuroleptic drugs. In: Lipton MA, Di-Mascio A, Killam KF (eds) Psychopharmacology. A generation of progress. Raven, New York, pp 1057–1071Google Scholar
  2. 2.
    Carroll BJ, Feinberg M, Greden JF et al. (1981) A specific laboratory test for melancholia. Arch Gen Psychiatry 38:15–22PubMedGoogle Scholar
  3. 3.
    Cook L, Davidson AB (1978) Behavioral pharmacology: Animal models involving aversive control of behavior. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology. A generation of progress. Raven, New York, pp 563–569Google Scholar
  4. 4.
    Delay I, Deniker P, Harl JM (1952) Utilisation en thérapeutique psychiatrique d’une phénothiazine d’action centrale élective (4560 RP). Ann Med Psychol 112:85–96Google Scholar
  5. 5.
    Haberman SJ (1978) Analyses of qualitative data, vol 1: Introductory topics; vol 2: New developments. Academic Press, New YorkGoogle Scholar
  6. 6.
    Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278–296PubMedCrossRefGoogle Scholar
  7. 7.
    Kessler KA (1978) Tricyclic antidepressants: Mode of action and clinical use. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology. A generation of progress. Raven, New York, pp 1289–1303Google Scholar
  8. 8.
    Kirkegaard C, Norlem N, Lauridsen ÜB, Bjørum N (1975) Prognostic value of thyro-tropin-releasing hormone stimulation test in endogenous depression. Acta Psychiatr Scand 52:170–177PubMedCrossRefGoogle Scholar
  9. 9.
    Kuhn R (1957) Über die Behandlung depressiver Zustände mit einem Iminodibenzyl-derivat (G22355). Schweiz Med Wochenschr 87:1135–1140PubMedGoogle Scholar
  10. 10.
    Langer G, Aschauer H, Koinig G, Resch F, Schönbeck G (1983) The TSH response to TRH: A possible predictor of outcome of antidepressant and neuroleptic treatment. Prog Neuropsychopharmacol 7:335–342CrossRefGoogle Scholar
  11. 11.
    Langer G, Heimann H (1983) Psychopharmaka: Grundlagen und Therapie. Springer, Berlin Heidelberg New YorkGoogle Scholar
  12. 12.
    Langer G, Aschauer H, Koinig G, Resch F, Schönbeck G, Keshavan MS TSH response to TRH predicts outcome to antidepressant and neuroleptic medication. Arch Gen Psychiatry (submitted)Google Scholar
  13. 13.
    Levine J (1978) Psychotropic drugs assessment: Current Status and future prospects. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology. A generation of progress. Raven, New York, pp 827–833Google Scholar
  14. 14.
    Loosen PT, Prange AJ (1983) Serum thyreotropin response to thyreotropin-releasing hormone in psychiatric patients: A review. Am J Psychiatry 139:405–415Google Scholar
  15. 15.
    Murphy DL, Campbell I, Costa JL (1978) Current Status of the indoleamine hypothesis of the affective disorders. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology. A generation of progress. Raven, New York, pp 1235–1249Google Scholar
  16. 16.
    Overall JE, Gorham IV, Aviano SL (1970) The brief psychiatric rating scale. Manual for the ECDEU assessment battery. Guy & Bonato, Chevy ChaseGoogle Scholar
  17. 17.
    Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria (RDC) for a selected group of functional disorders, 3rd edn. N.Y.S. Psych. Institute, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • G. Schönbeck
  • G. Langer
  • H. Aschauer
  • G. Koinig
  • F. Resch

There are no affiliations available

Personalised recommendations