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Fibrin Sealant and Its Modes of Application

  • H. Redl
  • G. Schlag

Abstract

After reconstitution, the two components of fibrin sealant — sealer protein/aprotinin and thrombin/CaCl2 solution - can —be applied in different ways. Besides sequential application or premixing of the reactant, application of the sealant components with the double-syringe applicator (Duploject) is advantageous in a number of ways, e.g., single-handed operation, thorough mixing, thin-layer application. Use of the Duploject is almost universally applicable. Thrombin concentration can be varied depending on the need for rapid or slow clotting of the sealants. The sealant can be delivered using needles, spray heads, or catheters, as indicated by the specific application. The spraying catheter can be easily used through the biopsy channel of an endoscope. Furthermore special micro-application techniques are possible. Fibrin sealant may also be used in connection with other biomaterials such as collagen (fleece), dura, and vascular grafts. Tests are reported on different collagen fleeces as well as on the addition of antibiotics. Finally visibility (including X-ray) and histological techniques are discussed.

Key words

antibiotics collagen fleece Duploject system fibrin glue hemostasis spray tissue adhesive tissue sealing wound healing 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. Redl
  • G. Schlag

There are no affiliations available

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