Abstract
After reconstitution, the two components of fibrin sealant — sealer protein/aprotinin and thrombin/CaCl2 solution - can —be applied in different ways. Besides sequential application or premixing of the reactant, application of the sealant components with the double-syringe applicator (Duploject) is advantageous in a number of ways, e.g., single-handed operation, thorough mixing, thin-layer application. Use of the Duploject is almost universally applicable. Thrombin concentration can be varied depending on the need for rapid or slow clotting of the sealants. The sealant can be delivered using needles, spray heads, or catheters, as indicated by the specific application. The spraying catheter can be easily used through the biopsy channel of an endoscope. Furthermore special micro-application techniques are possible. Fibrin sealant may also be used in connection with other biomaterials such as collagen (fleece), dura, and vascular grafts. Tests are reported on different collagen fleeces as well as on the addition of antibiotics. Finally visibility (including X-ray) and histological techniques are discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Guttmann J (1979) Untersuchung eines Fibrinklebers für die Anwendung in der Chirurgie peripherer Nerven. Diplomarbeit, Technische Universität Wien
Seelich T, Redl H (1980) Theoretische Grundlagen des Fibrinklebers. In: Schimpf K (ed) Fibrinogen, Fibrin und Fibrinkleber. FK Schattauer-Verlag, Stuttgart, New York (1980) 199–208
Redl H, Stanek G, Hirschl A, Schlag G (1982), Fibrinkleber-Antibiotika-Gemische — Festigkeit und Elutionsverhalten. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 18–21
Redl H, Schlag G, Stanek G, Hirschl A, Seelich T (1983) In vitro properties of mixtures of fibrin seal and antibiotics. Biomaterials 4: 29–32
Duckert F, Nyman D, Gastpar H (1978) Factor XIII fibrin and collagen. Coll Platelet Interact., FK Schattauer-Verlag, Stuttgart, New York, pp 391–396
Redl H, Schlag G (1986) Properties of different tissue sealants with special emphasis on fibrinogen based preparations. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine. Springer-Verlag, Heidelberg, Berlin, this volume
Pflüger H, Redl H (1982) Abbau von Fibrinkleber in vivo und in vitro (Versuche an der Ratte mit besonderer Berücksichtigung der klinischen Relevanz). Z Urol Nephrol 75: 25–30
Redl H, Schlag G, Dinges HP, Kuderna H, Seelich T (1982) Background and methods of fibrin sealing. In: Winter D, Gibbons DF, Plenk H (eds) Biomaterials. John Wiley and Sons Ltd (1982) 669-676
Stemberger A, Fritsche HM, Haas S, Spilker G, Wriedt-Lübbe I, Blümel G (1982) Biochemische und experimentelle Aspekte der Gewebeversiegelung mit Fibrinogen und Kollagen. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 290–293
Schlag G, Redl H, Thurnher M, Dinges HP (1986) The importance of fibrin in wound repair. In: Schlag G, Redl H (eds) Principles of fibrin sealant. Springer-Verlag, Heidelberg, Berlin, in press
Matras H, Dinges HP, Lassmann H, Mamoli B (1972) Zur nahtlosen interfaszikulären Nerventransplantation im Tierexperiment. Wr Med Wschr 122: 517
Redl H, Schlag G, Dinges HP (1982) Methods of fibrin seal application. Thorac Cardiovasc Surg 30: 223–227
Seelich T, Redl H (1979) Biochemische Grundlagen zur Klebemethode. Dtsch Z Mund-Kiefer-Gesichtschir 3: 22S-26S
Tange RA (1986) A new application method for fibrin sealant: glue gun. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine — otorhinolaryngology. Springer-Verlag, Heidelberg, Berlin, this volume
Redl H, Schlag G (1984) Background and methods of fibrin sealing. In: Skjoldborg H (ed) Scientific Workshop’ 82: Tisseel/Tissucol-Symposium — Areas of application, problems and perspectives in current surgery. Immuno Denmark, pp 11-19
Chüden HG (1986) Simplified application of fibrinous glue in middle-ear surgery. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine — otorhinolaryngology. Springer-Verlag Heidelberg, Berlin, this volume
Servadio L (1983) Tisseal in liver surgery. (Film)
Pers M (1984) Scand. J. Plast. Reconstr. Surg. 17: 178
Riedmiller H, Thüroff JW (1985). In: Melchior H (ed.) Fibrinklebung in der Urologie. Springer-Verlag, Berlin Heidelberg New York, pp 71–76
Haverich A, Walterbusch G, Oelert H, Borst HG (1984) In: Scheele J (ed.) Fibrinklebung, Springer-Verlag, Berlin Heidelberg New York, pp 143–149
Pridun N, Heindl W, Redl H, Schlag G, Machacek E (1986) In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine, Springer-Verlag, Heidelberg, this volume
Jessen C, Sharma P (1985) Ann. Thorac. Surg. 39: 521
Pridun N, Heindl W (1983) Wr. Klin. Wochenschr. 133, Suppl. 75: 40
Buchwald J (1984) In: Scheele J (ed.) Fibrinklebung, Springer-Verlag, Heidelberg Berlin, New York, pp 169–172
Waclawiczek H, Wayand W, Chmelicek A (1986) In: Schlag G, Redl H (eds.) Fibrin sealant in operative medicine, Springer-Verlag, Heidelberg, this volume
Flicker M, Pesendorf FX, Redl H (1985) Wr. Med. Wochenschrift 135, Suppl. 90: 21
Armengol JR (1985) In: Schlag G, Redl H (eds.) Fibrin sealant in operative medicine, Springer-Verlag, Heidelberg, this volume
Linscheer WG, Fazio TL (1979) Control of upper gastrointestinal hemorrhage by endoscopic spraying of clotting factor. Gastroenterology 77: 642–645
Pridun N, Heindl W (1983) Fibrinspraytherapie beim Spontanpneumothorax. Wr Klin Wochenschr 133, Suppl 75: 40
Dinges HP, Redl H, Schlag G (1982) Histologische Techniken und tierexperimentelle Modelle zur Untersuchung der Wechselwirkung zwischen Fibrinkleber und Gewebe. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 44–51
Siedentop KH, Harris D, Loewy A (1983) Experimental use of fibrin tissue adhesive in middle ear surgery. Laryngoscope 93: 1310–1313
Ferry JD, Morrison PR (1950) Fibrin clots and methods for preparing the same. United States Patent, Dec 5, 2,533,004
Braun A, Schumacher G, Kratzat R, Heine WD, Pasch B (1980) Der Fibrin-Antibiotika-Verband im Tierexperiment zur lokalen Therapie des Staphylokokken infizierten Knochens. H Unfallheilkunde 148: 809
Bösch P, Lintner F, Braun F (1979) Die autologe Spongiosatransplantation unter Anwendung des Fibrinklebesystems im Tierexperiment. Wr Klin Wochenschr 91: 628
Stanek G, Bösch P, Weber P, Hirschl A (1980) Experimentelle Untersuchungen für das pharmakokinetische Verhalten lokal applizierter Antibiotika. Acta Med Austriaca 4, Suppl 20: 19
Wahlig H, Dingeldein E, Braun A, Kratzat R (1982) Fibrinkleber und Antibiotika — Untersuchungen zur Freisetzungskinetik. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie, Georg Thieme Verlag, Stuttgart, New York, pp 182
Richling B (1982) Homologous controlled-viscosity fibrin for endovascular embolization. Part. I: Experimental development of the medium. Acta Neurochir 62: 159
Heine WD, Braun A, Edinger D (1982) Gewebliche Abwehrreaktionen auf das Fibrinklebesystem. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 277
Barrett PN, Dorner F, Eibl J (1986) In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine. Springer-Verlag, Heidelberg, Berlin, this volume
Eder G, Neumann M, Cerwenka R, Baumgarten K. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine. Springer-Verlag, Heidelberg, Berlin, this volume
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Redl, H., Schlag, G. (1986). Fibrin Sealant and Its Modes of Application. In: Schlag, G., Redl, H. (eds) Fibrin Sealant in Operative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71359-0_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-71359-0_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16734-1
Online ISBN: 978-3-642-71359-0
eBook Packages: Springer Book Archive