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Morphological Tumor Markers pp 47–69Cite as

Immunohistochemical Methods for the Demonstration of Tumor Markers

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Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 77))

Abstract

Immunhistochemistry plays a major role in biological and biomedical research as well as in diagnostic histopathology. In pathology, it has not only contributed significantly to our understanding of basic pathogenetic principles but also to the precision of diagnosis (see TAYLOR and KLEDZIK 1981; DE LELLIS et al. 1979; for further information). An accurate classification of neoplasms is an important prerequisite of the newly developed specific and highly efficient therapeutic approaches in oncology. A major problem in histopathology is the identification and classification of tumors on the basis of light microscopic appearance in routinely stained and processed sections. This task is relatively easily accomplished in well differentiated neoplasms with (more or less) close resemblance to the respective non-neoplastic tissue, but may be difficult or even impossible in undifferentiated tumors and in small tissue fragments. In these situations, the evaluation of tumor cell constituents or products (tumor markers) is a valuable supplement for refinement of diagnosis. The family of tumor markers includes various immunoglobulin classes in tumors or atypical proliferative conditions of lymphoreticular origin, hormones, particularly in endocrine tumors, tumor cell constituents, such as membrane and cytoskeletal components, and oncofetal substances (for further information see HEYDERMA 1983 and this volume).

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  1. H. Denk
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  1. Institut für Pathologie, Universität Hamburg, Martinistraße 52, D-2000, UKE, Hamburg 20, Germany

    Gerhard Seifer

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Denk, H. (1987). Immunohistochemical Methods for the Demonstration of Tumor Markers. In: Seifer, G. (eds) Morphological Tumor Markers. Current Topics in Pathology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71356-9_3

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