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Morphological Tumor Markers pp 223–243Cite as

Basal Membrane Antigens as Tumor Markers

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Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 77))

Abstract

In multicellular organisms the basal membrane, a complex extracellular matrix, plays a leading role in maintenance of the structure and function of the organism (VRACKO 1974, 1982; HAY 1978; FURTHMAYR 1982; STANLEY et al. 1982a, b; FOIDART 1984; ABRAHAMSON 1986; INGBER et al. 1986). The basal lamina (basement membrane, basement lamina) is primarily defined by its topography and structure, as revealed by light and electron microscopy. The electron microscopical analysis reveals three different zones: lamina densa, lamina rara (sive lucida), lamina densa. It is well known that the connective tissue matrix is composed of collagens, proteoglycans and glycoproteins, which influence the differentiation of the cells, their morphogenesis and the tendency to proliferation. MARTINEZ-HERNANDEZ and AMENTA (1983) have divided the substances composing the basal membrane into those which are intrinsic (collagen type IV, laminin, heparan sulfate proteoglycan, entactin) and those which are extrinsic (fibronectin and type V collagen).

Supported by the Deutsche Forschungsgemeinschaft and by the Hamburger Stiftung zur Förderung der Krebsbekämpfung

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Authors
  1. J. Caselitz
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  1. Institut für Pathologie, Universität Hamburg, Martinistraße 52, D-2000, UKE, Hamburg 20, Germany

    Gerhard Seifer

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© 1987 Springer-Verlag Berlin Heidelberg

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Caselitz, J. (1987). Basal Membrane Antigens as Tumor Markers. In: Seifer, G. (eds) Morphological Tumor Markers. Current Topics in Pathology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71356-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-71356-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71358-3

  • Online ISBN: 978-3-642-71356-9

  • eBook Packages: Springer Book Archive

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