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Hepatitis Delta Virus (HDV): Infection and Disease

  • Conference paper
Viral Hepatitis

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

First described in Italian patients with chronic hepatitis B virus (HBV) infection (Rizetto et al. 1977), the delta antigen was initially considered a variant of HBV. Characterization studies in chimpanzees have instead shown that it is the internal component of a new and unique hepatitis agent, which has peculiar biological features, and requires the assistance of HBV to replicate (Rizzetto et al. 1980a). The delta agent has been recently renamed hepatitis delta virus (HDV), the internal antigen (HD-Ag) and the antibody evoked in infected hosts anti-HD (Jacobson and Dienstag 1984). The clinical significance of the new pathogen is now evident on a global scale; the HDV represents an important etiologic agent responsible for severe forms of hepatitis (Rizzetto 1983).

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Author information

Authors and Affiliations

  1. Division of Gastroenterology, Molinette, Torino, Italy

    M. Rizzetto

  2. Clinica Medica I, University of Cagliari, Italy

    M. Rizzetto

Authors
  1. P. Farci
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  2. M. Rizzetto
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Editor information

Editors and Affiliations

  1. Histochemistry Unit, 1st Department of Pathology Spedali Civili of Brescia, Aggregaat Hoger Onderwijs, Catholic University of Leuven, 25100, Brescia, Italy

    Francesco Callea

  2. 1st Department of Pathology, Spedali Civili of Brescia, 25100, Brescia, Italy

    Mario Zorzi (Professor of Pathology and Chairman) (Professor of Pathology and Chairman)

  3. Laboratory of Histochemistry and Cytochemistry, Catholic University of Leuven, 3000, Leuven, Belgium

    Valeer J. Desmet (Professor of Pathology) (Professor of Pathology)

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© 1986 Springer-Verlag Berlin Heidelberg

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Farci, P., Rizzetto, M. (1986). Hepatitis Delta Virus (HDV): Infection and Disease. In: Callea, F., Zorzi, M., Desmet, V.J. (eds) Viral Hepatitis. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71350-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-71350-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71352-1

  • Online ISBN: 978-3-642-71350-7

  • eBook Packages: Springer Book Archive

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