Abstract
The treatment of chronic active hepatitis due to virus B (HBV) is not as satisfactory as with other forms of chronic hepatitis. The best results follow recognition of the natural history of the disease and whether the problem is that of the infectious, virus-replicating patient or the relatively non-infectious one without viral replication (Sherlock 1985) (Fig. 1). The problem of the individual must be considered, whether it is largely infectivity, symptoms or liver failure. The mode of action of any therapeutic agent must also be understood.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bréchot C, Hadchouel M, Scotto J, Fonck M, Potet F, Vyas GN, Tiollais P (1981) State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and negative liver disease. Proc Natl Acad Sci USA 78: 3906
Caruso L, Weber JN, Forster GE, Scully L, Harris TRW, Thomas HC (1985) Effects of HTLV III virus infection on replication, severity of liver disease and response to interferon in chronic hepatitis B virus carriers. J Hepatol Suppl 2: 207
Craxi A, Weller IVD, Bassendine MF, Fowler MJ, Monjardino J, Thomas HC, Sherlock S (1983) Relationship between HBV-specific DNA polymerase in chronic HBV infection: factors determining selection of patients and outcome of antiviral therapy. Gut 24: 143
Conn HO, Maddrey WC, Soloway RD (1982) The detrimental effects or adrenocorticosteroid therapy in HBsAg-positive chronic hepatitis: facts or artefact? Hepatology 2: 885
Dusheiko G, Dibisceglie A, Bowyer S, Sachs E, Ridche EM, Schoub B, Kew M (1985) Recombinant leukocyte interferon treatment of chronic hepatitis B. Hepatology 5: 556
Farci P, Karayiannis P, Smedile A, Gerin J, Thomas HC (1985) Chronic delta virus infection: response to lymphoblastoid interferon. J Hepatol 1, Suppl 2: 227
Gregory PB (1984) Antivirals in chronic hepatitis B — problems of small clinical trials. Gastroenterology 86: 201
Hoofnagle JH, Hanson RG, Minuk GY, Pappas Sc, Shafer DF, Dusheiko GM, Straus SE, Popper H, Jones EA (1984) Randomized controlled trial of adenine arabinoside 5-monophosphate for chronic type B hepatitis. Gastroenterology 86: 150
Ikeda T, Lever AML, Thomas HC (1985) Deficient production of interferon alpha predispose to chronic hepatitis B infection. J Hepatol Suppl 2: 256
Lok ASF, Karayiannis P, Brown D, Fowler MJ, Monjardino J, Thomas HC, Sherlock S (1984) Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication. Liver 4: 45
Lok ASF, Novick DM Karayiannis P (1986) A randomized study of the effects of adenine arabinoside 5-monophosphate (short or long courses) and lymphoblastoid interferon on hepatitis B virus replication. Hepatology (in press)
Nouri-Aria KT, Magrin S, Anderson GJM, Alexander GJM, Eddlestone ALWF, Williams R (1985) Interleukin-2 receptor expression before and after in vitro and interferon treatment in chronic hepatitis B virus (HBV) infection. J Hepatol Suppl 2: 298
Omata M, Imazeki F, Yokosuka O, Ito Y, Uchiumi K, Mori T, Okuda K (1985) Recombinant leukocyte A interferon treatment in patients with chronic hepatitis B virus infection. Gastroenterology 88: 870
Perrillo RP, Regenstein FG, Bodicky CJ, Campbell CR, Sanders GE, Sunwoo YC (1985) Comparative efficiency of adenine arabinoside 5’-monophosphate and prednison withdrawal followed by adenine arabinoside 5’-monophosphate in the treatment of chronic active hepatitis type B. Gastroenterology 88: 780
Pones JC, Carreno V, Mora I, Gutiez G, Quiroga JA, Bartolomé J, Cortez J, Hernandez J (1985) Changes of viral markers and liver histology in patients treated during six months with recombinant interferon. J Hepatol Suppl 2: 312
Robinson WS, Garcia G (1985) Interferon and hepatitis B. Hepatology 5: 336
Sagnelli E, Piccino F, Manzillo G, Felaco FM, Filippini P, Maio G, Pasquale G, Izzo CM (1983) Effect of immunosuppressive therapy on HBsAg-positive active hepatitis in relation to presence or absence of HBeAg and anti-HBe. Hepatology 3: 690
Scullard GH, Robinson WS, Merigan TC, Robinson WS, Gregory PB (1979) The effect of immunosuppressive therapy on hepatitis B viral infection in patients with chronic hepatitis. Gastroenterology 77: 43A
Scully LJ, Shein R, Lok ASF, Thomas HC (1985) Factors determining response rate to antiviral therapy in chronic hepatitis B infection. J Hepatol Suppl 2: 328
Sherlock S, Thomas HC (1983) Hepatitis B virus infection: the impact of molecular biology. Hepatology 3: 455
Sherlock S, (1985) Chronic hepatitis. In: Diseases of the liver and biliary system, 7th ed, Blackwell-Mosby, Oxford St. Louis, p 295
Shafritz DA, Shouval D, Sherman HI, Hadziyannis ST, Kew M (1981) Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. New Engl J Med 35: 1067
Smedile A, Farci P, Verme G, Caredda F, Cargnel A, Caporaso N, Dentico P, Trepo C, Opolon P, Gimson A, Vergani D, Williams R, Rizzetto M (1982) Influence of delta infection on severity of hepatitis B. Lancet 2: 945
Villa E, Rubbiani L, Barchi T, Ferret I, Grisendi A, De Palma M, Bellentani S, Manenti F (1982) Susceptibility of chronic symtomless HBsAg carriers to ethanol-induced hepatic damage. Lancet ii: 1243
Weller IVD, Fowler MF, Monjardino J, Thomas HC (1982a) The detection of HBV-DNA in serum by molecular hybridisation—a more sensitive method for the detection of complete HBV particles. J Med Virol 9: 273
Weller IVD, Carreno V, Fowler MF, Monjardino J, Makinen D, Thomas HC, Sherlock S (1982b) Acyclovir inhibits hepatitis B virus replication in man. Lancet i: 273
Weller IVD, Bassendine MF, Craxi A, Fowler MJ, Monjardino J, Thomas HC, Sherlock S (1982c) Successful treatment of HBs and HBeAg positive chronic liver disease: prolonged inhibition of viral replication by highly soluble adenine arabinoside 5-monophosphate (ARA-AMP). Gut 23: 717
Weller IVD, Bassendine MF, Murray A, Craxi A, Thomas HC, Sherlock S, (1982d) The effects of prednisolone/azathioprine in chronic hepatitis B viral infection. Gut 23: 650
Weller IVD, Lok ASF, Mindel A, Karayiannis P, Galpin S, Monjardino J, Sherlock S, Thomas HC (1985) Randomised controlled trial of adenine arabinoside 5-monophosphate (ARA-AMP) in chronid hepatitis-B virus infection. Gut 26: 745
Wu Pc, Lai CL, Lam KC, Ho J (1982) Prednisolone in HBsAg-positive chronic active hepatitis: histologic evaluation in a controlled prospective study. Hepatology 2: 777
Yokosuka O, Omata M, Imazeki F, Hirota K, Mori I, Uchiumi K, Ito Y, Okuda K (1985) Combination of short-term prednisolone and adenine arabinoside in the treatment of chronic hepatitis B. A controlled study. Gastroenterology 89: 246
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sherlock, S. (1986). The Treatment of Chronic Hepatitis Due to Hepatitis B Virus. In: Callea, F., Zorzi, M., Desmet, V.J. (eds) Viral Hepatitis. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71350-7_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-71350-7_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71352-1
Online ISBN: 978-3-642-71350-7
eBook Packages: Springer Book Archive