Superficial Infection With or Without Toxinogenesis

  • Akira Wake
  • Herbert R. Morgan
Part of the Springer Series in Molecular Biology book series (SSMOL)


Pathogenic organisms causing superficial infections colonize certain local parts of the surface barriers of the host body and initiate multiplication. The localizing part is generally unique to each microorganismic species, e.g., either of skin, respiratory or digestive tract, etc., but infection is usually limited without spreading from that region. The reason pathogenic microorganisms cause diseases in contrast to organisms of the normal flora, is that they succeed in establishing dominant “colonization” and usually elaborate toxins or other bioactive substances which aid the invasiveness of these microorganisms into the adjacent epithelial stratums. However, the absence of additional virulence factor(s) required for penetration deeper into the tissue results in the characteristic process of exudative rather than invasive infection. Therefore, it is critical for extensive disease production that the organism elaborates toxins or other bioactive substances. Adhesive factors are also important because they make it possible for the organism to bind to the host-cell surfaces and thus to establish itself on these epithelial surfaces to initiate infection.


Virulence Factor Diphtheria Toxin Superficial Infection Chicken Embryo Model Cholerae 569B 
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Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Akira Wake
    • 1
  • Herbert R. Morgan
    • 2
  1. 1.Department of BacteriologyNational Institute of HealthShinagawa-ku, Tokyo 141Japan
  2. 2.School of Medicine and DentistryUniversity of RochesterRochesterUSA

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