Extracellular and Intracellular Destruction of Microorganisms
The strategy of host-defense mechanisms adopts diversified tactics against infections by microorganisms which were previously operationally classified into three categories: those that cause (1) superficial infection; (2) exudative (or partially invasive) infection; and (3) invasive (or penetrating) infection as was described in Part I. The principal mechanisms operating can also be designated correspondingly as superficial defense against the first, extracellular destruction of pathogenic microorganisms against the second, and that encompassing intracellular destruction against the third category of invasive infection. However, this designation of these principal mechanism is not definitive because host-parasite relationships constitute a field as a whole in which all components of host-defense mechanisms can function simultaneously or separately in parallel against a variety of microorganismic virulence factors. From this point of view, the mechanisms responsible for extracellular and intracellular destruction of microorganisms will be discussed before the more general concept of host reaction to the external stimuli, i.e., inflammation.
KeywordsCholesterol Superoxide Heparin Respiration Polysaccharide
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