Factors Influencing Motor Nerve Growth
By far the best-characterized factor affecting nerve growth is the nerve growth factor (NGF), identified in 1956 by Cohen and Levi-Montalcini (for review, see Thoenen and Barde 1980), and subsequently sequenced and cloned. The purified protein has three major effects on sympathetic and sensory neurons cultured at appropriate development stages: it is required for cell survival, and enhances neurite outgrowth and neurotransmitter synthesis.
KeywordsNerve Growth Factor Neurite Outgrowth Sympathetic Innervation Spinal Neuron Spinal Cord Cell
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