Skip to main content
SpringerLink
Log in

Funktion sensorischer Substanz-P-Neurone

  • Chapter
Schmerztherapie

Part of the book series: Klinische Anästhesiologie und Intensivtherapie ((KAI,volume 32))

Zusammenfassung

Die Übertragung von Nervenimpulsen erfolgt bei höheren Tieren durch chemische Transmittersubstanzen. Für efferente Systeme des peripheren Nervensystems sind Azetylcholin und Noradrenalin als Überträgerstoffe seit Jahrzehnten bekannt. Wenig Klarheit herrscht aber bezüglich der Überträgerstoffe afferenter Nerven. Aminosäuren werden als Transmitter diskutiert. In den letzten Jahren wurde klar, daß auch höhermolekulare Peptide als Neurotransmitter oder Neuromodulatoren fungieren können. In einigen Neuronen kommen sowohl ein klassischer Transmitter als auch ein Peptid vor, welches die physiologische Funktion des ersteren moduliert. So koexistieren in einigen parasympathischen Neuronen Azetylcholin und vasoaktives intestinales Polypeptid (VIP), in postganglionär sympathischen Neuronen Noradrenalin und Neuropeptid Y (NPY). In sensorischen Neuronen wurden die Peptide Substanz P, Sornatostatin, VIP, ein Cholezystokinin- ähnliches Peptid und mit ziemlicher Sicherheit zwei weitere Peptide nachgewiesen (9j. Das Wissen über Substanz P ist am größten und man hat eine gewisse Vorstellung über die Rolle von Substanz P bei physiologischen und pathophysiologischen Vorgängen. Die Funktion der anderen sensorischen Peptide ist noch unklar.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. AKERMAN, B., ROSELL, S., FOLKERS, K.: Intrathecal (D-Pro2, D-Trp7,9) SP elicits hypoalgesia and motor blockade in the rat and antagonizes noxious responses induced by substance P. Acta physiol. scand. 114, 631 (1982)

    Article  PubMed  CAS  Google Scholar 

  2. BARBER, R. P., VAUGHN, J. E., SLEMM0N, J. R., SALVATERRA, P. M., ROBERTS, E., LEEMAN, S. E.: The origin, distribution and synaptic relationships of substance P axons in rat spinal cord. J. comp. Neurol. 184, 331 (1979)

    Article  PubMed  CAS  Google Scholar 

  3. BILL, A., STJERNSCHANTZ, J., MANDAHL, A., BR0DIN, E., NILSSON, G.: Substance P: Release on trigeminal nerve Stimulation, effects in the eye. Acta physiol. scand. 106, 371 (1979)

    Article  PubMed  CAS  Google Scholar 

  4. FITZGERALD, M.: Capsaicin and sensory neurones — a review. Pain 15, 109 (1983)

    Article  PubMed  CAS  Google Scholar 

  5. GAMSE, R.: Capsaicin and nociception in the rat and mouse. Naunyn-Schmiedeberg’s Arch. Pharmacol. 320, 205 (1982)

    CAS  Google Scholar 

  6. GAMSE, R., MOLNAR, A., LEMBECK, F.: Substance P release from spinal cord slices by capsaicin. Life Sei. 25, 629 (1979)

    Article  CAS  Google Scholar 

  7. HARMAR, A., SCHOFIELD, J. G., KEEN, P.: Substance P biosynthesis in dorsal root ganglia: An immunochemical study of (35s) Methionine and (3h) Proline incorporation in vitro. Neuroscience 6, 1917 (1.981)

    Google Scholar 

  8. HENRY, J. L.: Effects of substance P on functionally identified units in cat spinal cord. Brain Res. 114, 439 (1976)

    Article  PubMed  CAS  Google Scholar 

  9. HÖKFELT, T., JOHANSSON, O., LJUNGDAHL, A., LUNDBERG, J. M., SCHULTZBERG, M.: Peptidergic neurons. Nature 284, 515 (1980)

    Article  PubMed  Google Scholar 

  10. HÖKFELT, T., KELLERTH, J. O., NILSSON, G., PERNOW, B.: Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res. 100, 235 (1975)

    Article  PubMed  Google Scholar 

  11. HOLMDAHL, H., HANKANSON, R., LEANDER, S., ROSELL, S., FOLKERS, K., SUNDLER, F.: A substance P antagonist, (D-Pro2, D-Trp7,9) SP, inhibits inflammatory responses in the rabbit eye. Science 214, 1029 (1981)

    Article  PubMed  CAS  Google Scholar 

  12. JANCSO, G., KIRÄLY, E., JANCSO-GABOR, A.: Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature 270, 741 (1977)

    Article  Google Scholar 

  13. HYLDEN, J. L. K., WILCOX, G. L.: Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice. Brain Res. 217, 21. 2 (1981)

    Google Scholar 

  14. LEE, C. M., SANDBERG, B. E. B., HANLEY, M. R., IVERSEN, L. L.: Purification and characterization of a membrane- bound substance P-degrading enzyme from human brain. Europ. J. Biochem. 114, 315 (1981)

    Article  PubMed  CAS  Google Scholar 

  15. LEMBECK, F.: Mediators of vasodilatation in the skin. Brit. J. Dermatoi. 109, Suppl. 25, 1 (1983)

    Google Scholar 

  16. LEMBECK, F., DONNERER, J., BARTHO, L.: Inhibition of neurogenic vasodilatation and plasma extravasation by substance P antagonists, somatostatin and D-Pro2, Met5-enkephalinamide. Europ. J. Pharmacol. 85, 171 (1982)

    Article  CAS  Google Scholar 

  17. LEMBECK, F., DONNERER, J., COLPAERT, F. C.: Increase of substance P in primary afferent nerves during chronic pain. Neuropeptides 1, 175 (1981)

    Article  CAS  Google Scholar 

  18. LEMBECK, F., FOLKERS, K., DONNERER, J.: Analgesie effect of antagonists of substance P. Biochem. biophys. Res. Commun. 103, 1318 (1981)

    CAS  Google Scholar 

  19. LEMBECK, F., HOLZER, P.: Substance P as neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. Naunyn-Schmiedeberg’s Arch. Pharmacol. 310, 175 (1979)

    CAS  Google Scholar 

  20. LUNDBERG, J. M., HÖKFELT, T., MARTLING, C.-R., SARIA, A.: Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tiss. Res. 235, 251 (1984)

    CAS  Google Scholar 

  21. LUNDBERG, J. M., MARTLING, C.-R., SARIA, A., FOLKERS, K., ROSELL, S.: Cigarette smoke-induced airway oedema due to activation of capsaicin-sensitive vagal afferents and substance P release. Neuroscience 10, 1361 (1983)

    Article  PubMed  CAS  Google Scholar 

  22. LUNDBERG, J. M., SARIA, A., BRODIN, E., ROSELL, S., FOLKERS, K.: A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea-pig. Proc. nat. Acad. Sei. (Wash.) 80, 1120 (1983)

    Article  CAS  Google Scholar 

  23. NAGY, J. I., IVERSEN, L. L., GOEDERT, M., CHAPMAN, D., HUNT, S. P.: Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J. Neurosci. 3, 399 (1982)

    Google Scholar 

  24. NAWA, H., HIROSE, T., TAKASHIMA, H., INAYAMA, S., NAKANISHI, S.: Nucleotide seguences of cloned cDNAs for two types of bovine brain substance P precursors. Nature 306, 32 (1983)

    Article  PubMed  CAS  Google Scholar 

  25. PERNOW, B.: Studies on substance P. Purification, occurence and biological actions. Acta physiol. scand. 29, Suppl. 105, 1 (1953)

    Article  CAS  Google Scholar 

  26. PERNOW, B.: Substance P. Pharmacol. Rev. 35, 85 (1983)

    CAS  Google Scholar 

  27. PIERCEY, M. F., SCHROEDER, L. A., FOLKERS, K., XU, J. C., HÖRIG, J.: Sensory and motor functions of spinal cord substance P. Science 214, 1361 (1981)

    Article  PubMed  CAS  Google Scholar 

  28. RODRIGUEZ, R. E., SALT, T. E., CAHUSAC, P. M., HILL, R. G.: The behavioural effects of intrathecally administered (D-PR02, D-TRP7,9)-Substance P, an analogue with presumed antagonist actions, in the rat. Neuropharmacology 22, 173 (1983)

    Article  PubMed  CAS  Google Scholar 

  29. SARIA, A.: Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury. Brit. J. Pharmacol. 82, 217 (1984)

    CAS  Google Scholar 

  30. SARIA, A., LUNDBERG, J. M., SKOFITSCH, G., LEMBECK, F.: Vascular protein leakage in various tissues by substance P, capsaicin, bradykinin, Serotonin, histamine and by antigen challenge. Naunyn-Schmiedeberg’s Arch. Pharmacol. 324, 212 (1983)

    CAS  Google Scholar 

  31. YAKSH, T. L., JESSELL, T. M., GAMSE, R., MUDGE, A. W., LEEMAN, S. E.: Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Nature 286, 155 (1980)

    Article  PubMed  CAS  Google Scholar 

  32. ZIEGELGÄNSBERGER, W., TULLOCH, I. F.: Effects of substance P on neurones in the dorsal horn of the spinal cord of the cat. Brain Res. 166, 273 (1979)

    Article  Google Scholar 

Download references

Authors
  1. F. Lembeck
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Gamse
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung für Anästhesiologie und operative Intensivmedizin, Allgemeines öffentliches Krankenhaus, Krankenhausstraße 9, A-4020, Linz (Donau), Germany

    Hans Bergmann

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Lembeck, F., Gamse, R. (1986). Funktion sensorischer Substanz-P-Neurone. In: Bergmann, H. (eds) Schmerztherapie. Klinische Anästhesiologie und Intensivtherapie, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71333-0_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71333-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16698-6

  • Online ISBN: 978-3-642-71333-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation