Evidence for a Link Between Peroxisomes and the Nonspecific Lipid Transfer Protein (Sterol Carrier Protein 2) in Rat and Human Liver

  • A. Van Amerongen
  • J. B. Helms
  • M. Van Noort
  • F. F. G. Rommerts
  • K. W. A. Wirtz
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Antibodies against the nonspecific lipid transfer protein (nsL-TP) are cross-reactive with a high-molecular weight protein(s) found in the 105,000 x g supernatant and peroxisomes from rat and human liver. Levels of nsL-TP in Morris hepatoma 7777 and in the liver of Zellweger patients are greatly reduced as compared to controls (i.e. ten- to twenty-fold reduction). These tissues which are deficient in peroxisomes, do contain the high-molecular weight protein (s). This suggests that the occurrence of nsL-TP may depend on the presence of peroxisomes.

Levels of nsL-TP in the Leydig cells of rat testis are under hormonal control. Stimulation of rat tumor Leydig cells with luteinizing hormone doubled the levels of nsL-TP within two minutes under conditions where protein synthesis was inhibited. It remains to be established whether this post-translational processing involves cleavage of a high-molecular weight protein.


Luteinizing Hormone Leydig Cell Tumor Leydig Cell Sterol Carrier Protein Morris Hepatoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. Van Amerongen
    • 1
  • J. B. Helms
    • 1
  • M. Van Noort
    • 2
  • F. F. G. Rommerts
    • 2
  • K. W. A. Wirtz
    • 1
  1. 1.Laboratory of BiochemistryState UniversityUtrechtThe Netherlands
  2. 2.Department of Biochemistry (Division of Chemical Endocrinology)Erasmus UniversityRotterdamThe Netherlands

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