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Prevention of Peroxisomal Proliferation by Carnitine Palmitoyltransferase Inhibitors in Cultured Rat Hepatocytes and In Vivo

  • R. Hertz
  • J. Bar-Tana
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

The induction of peroxisomal β-oxidation activities by beza- fibrate in cultured rat hepatocytes as well as in the rat in vivo was prevented by inhibitors of carnitine acyltransferase, e.g., 2-bromopalmitate, 2- [5-(4-chloropheny1)-pentyl]-oxirane-2-carboxylate (POCA) or 2-tetradecylglycidic acid. Prevention of peroxisomal proliferation by carnitine acyltransferase inhibitors in culture could not be accounted for by inhibition of mitochondrial β-oxidation, since 2-bromooctanoate acting as an inhibitor of β-oxidation did not inhibit the induction of peroxisomal activities by bezafibrate. Prevention of peroxisomal proliferation by carnitine acyltransferase inhibitors in vivo was observed in the fasted but not in the fed rat, e.g., under conditions where the mitochondrial transport of carboxylic acids is mediated by the carnitine transferase activity. Hence, the carnitine acyltransferase activity seems to be directly involved in the induction of peroxisomal activities by xenobiotic peroxisomal proliferators.

Keywords

Peroxisomal Proliferation Carnitine Acyl Carnitine Acyltransferase Hadassah Medical School Peroxisomal Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • R. Hertz
    • 1
  • J. Bar-Tana
    • 1
  1. 1.Department of BiochemistryHebrew University — Hadassah Medical SchoolJerusalemIsrael

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