β-Oxidation Systems in Eukaryotic Microorganisms

  • W.-H. Kunau
  • C. Kionka
  • A. Ledebur
  • M. Mateblowski
  • M. Moreno De La Garza
  • U. Schultz-Borchard
  • R. Thieringer
  • M. Veenhuis
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


In yeasts and fungi capability to degrade fatty acids is not limited to some specialized species of Candida. For example, the methylotropic yeasts Hansenula polymorpha and Pichia pastoris, the methylamine-oxidizing yeast Trichosporon cutaneum, the filamentous fungus Neurospora crassa, and even Saccharomyces cerevisiae (baker’s yeast) possess an inducible, non-mitochondrial ß-oxidation system. The induction by oleate is associated with marked proliferation of microbodies.

Comparison of ß-oxidation proteins of microbodies purified from these eukaryotic microorganisms reveals that they share common features in structure and function with the corresponding peroxisomal proteins from higher eukaryotes. An interesting difference is the non-mitochondrial acyl-CoA dehydrogenase of N. crassa.

The ß-oxidation system in this fungus seems to be localized in a new type of microbodies, non-peroxisomal glyoxysomes. Preliminary evidence suggests that other fungi might contain a similar ß-oxidation system.


Pichia Pastoris Neurospora Crassa Eukaryotic Microorganism Peroxisomal Protein Fatty Acid Degradation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • W.-H. Kunau
    • 1
  • C. Kionka
    • 1
  • A. Ledebur
    • 1
  • M. Mateblowski
    • 1
  • M. Moreno De La Garza
    • 1
  • U. Schultz-Borchard
    • 1
  • R. Thieringer
    • 1
  • M. Veenhuis
    • 2
  1. 1.Institute of Physiological Chemistry, Ruhr-UniversityGermany
  2. 2.Biological CentreUniversity of GroningenHarenThe Netherlands

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