Histamine and Allergic Diseases

  • J. Ring
  • F. Sedlmeier
  • D. von der Helm
  • T. Mayr
  • U. Walz
  • H. Ibel
  • H. Riepel
  • B. Przybilla
  • H.-J. Reimann
  • W. Dorsch

Abstract

Although known for almost 80 years, histamine (H) (β-imidazolylethylamine) still remains a fascinating substance for many researchers. In spite of great progress in knowledge of pharmacology and release mechanisms as well as the discovery of other potent mediators, the definition of the physiological role of histamine in health and disease remains incomplete. The role of H — among others — as mediator of immediate-type hypersensitivity diseases (both allergic and pseudo-allergic in origin) is rather well established. This proinflammatory effect involves predominantly H1 receptors on mucosal cells, smooth muscle and vascular endothelium. Similarly well-defined is the H2-mediated role of H in gastric acid secretion. Less well defined is the clinical relevance of cardiac H1 and H2 receptors (atrial H1 receptors mediating negative dromotropic effects, while ventricular tachycardia is mediated by H2 receptors) as well as the role of H as neurotransmitter in the human brain.

Keywords

Morphine Flavonoid Androgen Indomethacin Prolactin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. Ring
    • 1
  • F. Sedlmeier
    • 1
  • D. von der Helm
    • 1
  • T. Mayr
    • 1
  • U. Walz
    • 1
  • H. Ibel
    • 1
  • H. Riepel
    • 1
  • B. Przybilla
    • 1
  • H.-J. Reimann
    • 2
  • W. Dorsch
    • 3
  1. 1.Dermatologische Klinik und Poliklinikder Ludwig-Maximilians-Universität MünchenMunichFederal Republic of Germany
  2. 2.II. Medizinische Klinikder Technischen Universität MünchenMunichFederal Republic of Germany
  3. 3.Kinderpoliklinikder Ludwig-Maximilians-Universität MünchenMunichFederal Republic of Germany

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