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Chemotactic Factors as Mediators of Allergy

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Book cover New Trends in Allergy II

Abstract

Mast cells are the central effector cells of acute allergic reactions. Besides histamine which has no significant chemotactic activity of its own, mast cells release other inflammatory mediators into their environment. Several of these factors have neutrophil or eosinophil chemotactic activities, such as leukotriene B4 (LTB4), platelet activating factor (PAF) and neutrophil chemotactic factor (NCF). Enzymes of mast cells can also activate the complement casade, resulting in the production of the potent chemotactic peptide C 5 a. Once inflammatory leukocytes have entered the site of allergic reaction, they can generate the same chemotactic mediators that are produced by mast cells. Chemotactic mediators serve to amplify and perpetuate mast cell-dependent allergic processes, and they induce chronic inflammatory changes and tissue damage in persistent, severe allergic reactions.

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Authors and Affiliations

  1. Universitäts-Hautklinik Münster, 4400, Münster, Federal Republic of Germany

    B. M. Czarnetzki

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  1. B. M. Czarnetzki
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Editors and Affiliations

  1. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Frauenlobstraße 9–11, 8000, Munich, Federal Republic of Germany

    Johannes Ring (Head: Prof. Dr. Dr. hc. O. Braun-Falco) & Günter Burg (Head: Prof. Dr. Dr. hc. O. Braun-Falco) (Head: Prof. Dr. Dr. hc. O. Braun-Falco) &  (Head: Prof. Dr. Dr. hc. O. Braun-Falco)

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© 1986 Springer-Verlag Berlin Heidelberg

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Czarnetzki, B.M. (1986). Chemotactic Factors as Mediators of Allergy. In: Ring, J., Burg, G. (eds) New Trends in Allergy II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71316-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-71316-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71318-7

  • Online ISBN: 978-3-642-71316-3

  • eBook Packages: Springer Book Archive

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