Biological Role of Major Transplantation Antigens in T Cell Self-recognition: Possible Consequences in Clinical Medicine
T cell restriction determines what antigens are immunogenic.
T cell restriction has to be taken into account for in vitro testing of cell-mediated immunity.
The specificity for self-MHC of T cells is determined during maturation in the thymus; therefore reconstitution of immunodeficiency depends on thymus grafts and bone marrow stem cells sharing MHC determinants.
T cell restriction may well give us one key to understand why some disease susceptibilities may be linked to the MHC (HLA in human, H-2 in mice).
KeywordsBone Marrow Stem Cell Major Histocompatibility Gene Complex Cell Restriction Lymphocytic Choriomeningitis Cell Effector Function
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