Presynaptic α-Adrenoceptor Control of Transmitter Release from Vascular Sympathetic Neurones in Vitro

  • O. A. Nedergaard


The documentation for the observation that depolarization-evoked adrenergic transmitter release from sympathetic neurones is decreased by α2-adrenoceptor agonists, while it is enhanced by α2-adrenoceptor antagonists seems overwhelming (Langer 1977, 1981; Starke 1977, 1981; Westfall 1977; Gillespie 1980; Vizi 1979). This has led to the autoreceptor theory, according to which noradrenaline release from sympathetic neurones is modulated by the neurogenic transmitter itself: activation of presynaptic α2-adrenoceptors initiates a negative feedback system which results in subsequent inhibition of transmitter release. Recently, this hypothesis has been challenged (Chan and Kalsner 1979; Kalsner 1979, 1980a, 1980b, 1981, 1982a, 1982b, 1983; Angus and Korner 1980; Angus et al. 1984).


Pulmonary Artery Transmitter Release Sympathetic Neurone Noradrenaline Release Presynaptic Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • O. A. Nedergaard
    • 1
  1. 1.Department of PharmacologyOdense University School of MedicineOdense CDenmark

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