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Presynaptic α-Adrenoceptor Control of Transmitter Release from Vascular Sympathetic Neurones in Vitro

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Book cover New Aspects of the Role of Adrenoceptors in the Cardiovascular System

Abstract

The documentation for the observation that depolarization-evoked adrenergic transmitter release from sympathetic neurones is decreased by α2-adrenoceptor agonists, while it is enhanced by α2-adrenoceptor antagonists seems overwhelming (Langer 1977, 1981; Starke 1977, 1981; Westfall 1977; Gillespie 1980; Vizi 1979). This has led to the autoreceptor theory, according to which noradrenaline release from sympathetic neurones is modulated by the neurogenic transmitter itself: activation of presynaptic α2-adrenoceptors initiates a negative feedback system which results in subsequent inhibition of transmitter release. Recently, this hypothesis has been challenged (Chan and Kalsner 1979; Kalsner 1979, 1980a, 1980b, 1981, 1982a, 1982b, 1983; Angus and Korner 1980; Angus et al. 1984).

Supported by P. Carl Petersen’s Fund and the Novo Foundation

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Authors and Affiliations

  1. Department of Pharmacology, Odense University School of Medicine, J. B. Winsløws Vej 19, 5000, Odense C, Denmark

    O. A. Nedergaard

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  1. O. A. Nedergaard
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Editor information

Editors and Affiliations

  1. Lehrstuhl für Pharmakologie, Universität Regensburg, Universitätsstraße 31, 8400, Regensburg, Federal Republic of Germany

    Horst Grobecker

  2. Institut für Pharmakodynamik und Toxikologie, Universität Innsbruck, Peter-Mayr-Straße 1, 6020, Innsbruck, Austria

    Athineos Philippu

  3. Pharmakologisches Institut, Universität Freiburg, Hermann-Herder-Straße 5, 7800, Freiburg i.Br., Federal Republic of Germany

    Klaus Starke

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© 1986 Springer-Verlag Berlin Heidelberg

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Nedergaard, O.A. (1986). Presynaptic α-Adrenoceptor Control of Transmitter Release from Vascular Sympathetic Neurones in Vitro. In: Grobecker, H., Philippu, A., Starke, K. (eds) New Aspects of the Role of Adrenoceptors in the Cardiovascular System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71313-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-71313-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71315-6

  • Online ISBN: 978-3-642-71313-2

  • eBook Packages: Springer Book Archive

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