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Presynaptic α-Adrenoceptor Control of Transmitter Release from Vascular Sympathetic Neurones in Vitro

  • O. A. Nedergaard

Abstract

The documentation for the observation that depolarization-evoked adrenergic transmitter release from sympathetic neurones is decreased by α2-adrenoceptor agonists, while it is enhanced by α2-adrenoceptor antagonists seems overwhelming (Langer 1977, 1981; Starke 1977, 1981; Westfall 1977; Gillespie 1980; Vizi 1979). This has led to the autoreceptor theory, according to which noradrenaline release from sympathetic neurones is modulated by the neurogenic transmitter itself: activation of presynaptic α2-adrenoceptors initiates a negative feedback system which results in subsequent inhibition of transmitter release. Recently, this hypothesis has been challenged (Chan and Kalsner 1979; Kalsner 1979, 1980a, 1980b, 1981, 1982a, 1982b, 1983; Angus and Korner 1980; Angus et al. 1984).

Keywords

Pulmonary Artery Transmitter Release Sympathetic Neurone Noradrenaline Release Presynaptic Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • O. A. Nedergaard
    • 1
  1. 1.Department of PharmacologyOdense University School of MedicineOdense CDenmark

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