Abstract
One of the consequences of the interaction of an infectious microorganism and its normal host is the selection of individuals with a genetic constitution which confers a survival advantage. In man the greater resistance to yellow fever in areas of Africa where the virus is endemic has been regarded as an example of this phenomenon (Sabin, 1954), although direct evidence is lacking. Experimental studies in mice have also established the occurrence of genetically determined resistance to infection with a number of infectious agents. The first observation of resistance to yellow fever virus in mice dates back over fifty years (Sawyer and Lloyd, 1931) and resistance was shown to be due to an inherited factor (Lynch and Hughes, 1936). Sabin (1952) working with mice of the PRI strain showed that an autosomal dominant gene conferred resistance, not only to yellow fever virus, but also to a number of other arthropod-borne viruses. These viruses are now known to be flaviviruses, and the genetically-determined resistance appears to be flavivirus specific (Sabin, 1952a; Hanson and Koprowski, 1969).
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© 1986 Springer-Verlag Berlin · Heidelberg
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Sangster, M.Y., Shellam, G.R. (1986). Genetically Controlled Resistance to Flaviviruses Within the House Mouse Complex of Species. In: Potter, M., Nadeau, J.H., Cancro, M.P. (eds) The Wild Mouse in Immunology. Current Topics in Microbiology and Immunology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71304-0_37
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DOI: https://doi.org/10.1007/978-3-642-71304-0_37
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