Gene-Specific Structures Within Class I Genes from Mus musculus domesticus are Conserved in Class I Genes from Mus pahari
The class I genes from the Major Histocompatibility Complex (MHC) of Mus musculus domestieus are a highly polymorphic multigene family (Klein 1981). The members of the present day family are thought to have evolved from a single ancestral gene by a number of complex molecular mechanisms ultimately controlled by natural selection. These include gene duplication (Steinmetz 1982; Weiss 1984), mutation, recombination (Artzt 1985), and gene conversion (Weiss 1983; Schulze 1983; Miyada 1985), There is little doubt that the class 1 gene family expanded by gene duplication and that mutational and recombinational events are responsible for the variation in size and organization of this family seen among different strains of Mus musculus domesticus (Weiss 1984; Rogers 1985) and among different vertebrate species (Ploegh 1981). However, there is some controversy concerning the mechanisms that have generated the polymorphism seen in Mus musculus. A considerable body of evidence suggests that much of the polymorphism existed before speciation of the genus Mus. According to this view the alleles have evolved independently and polymorphism has been maintaned by natural selection (Arden 1982).
KeywordsCodon Leukemia Recombination Sine Hunt
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