Abstract
The class II genes of the murine major histocompatibility complex (H-2) are a tightly linked cluster of highly polymorphic genes which encode molecules involved in the recognition of antigen by T lymphocytes. Biochemical analyses of class II molecules have identified two molecules, designated I-A and I-E, which are expressed on the surfaces of antigen presenting cells and B lymphocytes (Cullen et al. 1976; Uhr et al. 1979). Both molecules are integral membrane glycoproteins and each is a heterodimer formed by noncovalent interactions between an alpha (α) and beta (β) subunit.
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© 1986 Springer-Verlag Berlin · Heidelberg
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Wakeland, E.K., McIndoe, R.A., McConnell, T.J. (1986). Genetic Diversity of Class II Genes in Wild Mice: Definition of Five Evolutionary Groups by RFLP Analysis of Aα and Aβ . In: Potter, M., Nadeau, J.H., Cancro, M.P. (eds) The Wild Mouse in Immunology. Current Topics in Microbiology and Immunology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71304-0_29
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DOI: https://doi.org/10.1007/978-3-642-71304-0_29
Publisher Name: Springer, Berlin, Heidelberg
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