Abstract
The germline content of immunoglobulin (Ig) heavy and light chain variable region genes is one important source of antibody diversity; thus a large germline repetoire of these genes provides a potential capability to respond to a wide variety of antigens independent of subsequent somatic diversification. Immunoglobulin variable region genes appear to have evolved at a more rapid rate than many other proteins (Wilson 1977), which might be expected in a system where selection favors increased diversity. Examining evolutionary changes in immunoglobulin multigene families provides an opportunity to study the rate at which this system is evolving and permits an examination of the relative contribution of point mutations, recombinational events and gene duplications to the generation of germline diversity. The Ig repetoire of inbred Mus musculus, which has been extensively studied (for a review, see Honjo 1985, Hood 1985), represents an ideal model for such studies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brodeur PH, Riblet R (1984) The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse I. One hundred Igh-V genes comprise seven families of homologous genes. Eur J Immunol 14:922–930
Cory S, Tyler BM, Adams JM (1981) Sets of immunoglobulin VK genes homologous to ten cloned VK sequences: implications for the number of germline VK genes. J Mol Appl Genet 1:103–116
D’Hoostelaere LA, Potter M (submitted) Igk polymorphism in M. musculus domestieus populations from Maryland and Delaware. (this edition)
Hartman AB, Rudikoff S (1984) VH genes encoding the immune response to β-(1,6) -galactan: somatic mutation in IgM molecules. EMBO 3:3023–3030
Honjo T, Habu S (1985) Origin of immune diversity: genetic variation and selection. Ann Rev Biochem 54:803–830
Hood L, Kronenberg M, Hunkapiller T (1985) T cell antigen receptors and the immunoglobulin supergene family. Cell 40:225–229
Huang C-M, Parsars M, Oi VT, Huang H-JS, Herzenberg LA (1983) Genetic characterizaton of mouse immunoglobulin allotypic determinants (allotypes) defined by monoclonal antibodies. Immunogenetics 18: 311–321
Huppi K, Jouvin-Marche E, Scott C, Potter M, Weigert M (1985) Genetic polymorphism at the K chain locus in mice: comparison of restriction enzyme hybridization fragments of variable and constant region genes. Immunogenetics 21:445–457
Lieberman R (1978) Genetics of IgCH (allotype) locus in the mouse. Springer Seminars in Immunopathol 1:7–30
Mushinski EB, Potter M (1977) Idiotypes or galactan binding myeloma proteins and anti-galactan antibodies in mice. J Immunol 119: 1888–1893
Potter M, Mushinski EB, Rudikoff S, Glaudemans CPJ, Padlan EA, Davies DR (1979) Structural and genetic basis of idiotypes in the galactan-binding myeloma proteins. Ann Immunol (Inst Pasteur) 130C:263–271
Rudikoff S, Pawlita M, Pumphrey J, Mushinski E, Potter M (1983) Galactan-binding antibodies: diversity and structure of idiotypes. J Exp Med 158:1385–1400
Wilson AC, Carlson SS, White TJ (1977) Biochemical evolution. Ann Rev Biochem 46:573–639
Yonekawa H, Gotieh O, Tagashira Y, Matsushima Y, Shi L-I, Cho WS, Miyashita N, Moriwaki K (submitted) A hybrid origin of Japanese mice “Mus musculus molossinus.” (this edition)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Hartman, A.B., D’Hoostelaere, L.A., Potter, M., Rudikoff, S. (1986). The X-24 VH Gene Family in Inbred Mouse Strains and Wild Mice. In: Potter, M., Nadeau, J.H., Cancro, M.P. (eds) The Wild Mouse in Immunology. Current Topics in Microbiology and Immunology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71304-0_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-71304-0_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71306-4
Online ISBN: 978-3-642-71304-0
eBook Packages: Springer Book Archive