Comparative Pharmacodynamics of Benzodiazepines

  • E. H. EllinwoodJr.
  • A. M. Nikaido
  • D. G. Heatherly
Conference paper
Part of the Psychopharmacology Series book series (PSYCHOPHARM, volume 3)

Abstract

Dispositional pharmacokinetics have been shown to have little relationship to drug effects after acute doses of certain benzodiazepines (Ellinwood et al. 1983, 1985; Lader 1979; Ziegler et al. 1983). For diazepam the rapid onset of acute tolerance follows the peak behavioral effect; that is, impairment of performance in cognitive-neuromotor tests declines considerably faster than the corresponding serum drug concentration (Ellinwood et al. 1983, 1985). Other studies have described a relatively short period of impairment for high single doses of diazepam (George and Dundee 1977) and a more prolonged period of impairment for lorazepam (Seppala et al. 1976), although the elimination half-lives (t1/2) of diazepam and its active metabolite N-desmethyldiazepam (Mandelli et al. 1978) are over twice as long as that of lorazepam, which has no active metabolites.

Keywords

Placebo Fructose Diazepam Midazolam Chromato 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. H. EllinwoodJr.
  • A. M. Nikaido
    • 1
  • D. G. Heatherly
    • 1
  1. 1.Behavioral Neuropharmacology Section, Department of PsychiatryDuke University Medical CenterDurhamUSA

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