Skip to main content

Molecular Approach to the Mechanism of Action of Antidepressant Drugs

  • Conference paper
Clinical Pharmacology in Psychiatry

Part of the book series: Psychopharmacology Series ((PSYCHOPHARM,volume 3))

Abstract

In any attempt to explain the action of psychoactive drugs and neurotransmitters at the molecular level, in particular the binding and interaction with the receptor sites, it is of primary importance to elucidate the characteristic structural and conformational features of these compounds. This can be accomplished by analysis of SAR data (structure-activity relationship) for different types of drugs and related compounds.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Carnmalm B, Johansson L, Ramsby S, Stjernstrdm NE, Ross SB, Ögren SO (1976) Stereoselec-tive effects of the potentially neuroleptic rigid spiro amines. Nature 263: 519–520

    Article  PubMed  CAS  Google Scholar 

  • Horn AS, Post ML, Kennard O (1975) Dopamine receptor blockade of the neuroleptics, a crystallography study. J Pharm Pharmacol 27: 553–563

    Article  PubMed  CAS  Google Scholar 

  • Langer SZ, Raisman R, Briley MS (1980) Stereoselective inhibition of 3H-imipramine binding by antidepressant drugs and their derivatives. Eur J Pharmacol 64: 89–90

    Article  PubMed  CAS  Google Scholar 

  • Lindberg UH, Thorberg SO, Bengtsson S, Renyi AL, Ross SB, Ogren SO (1978) Inhibitors of neuronal monoamine uptake. 2 Selective inhibition of 5-hydroxytryptamine uptake by a- aminoacid esters of phenethyl alcohols. J Med Chem 21: 448–456

    Article  PubMed  CAS  Google Scholar 

  • Reith MEA, Sershen H, Lajtha A (1984) Thermodynamics of the interactions of tricyclic drugs with the binding sites for 3H-imipramine binding in mouse cerebral cortex. Biochem Pharmacol 33: 4101–4104

    Article  PubMed  CAS  Google Scholar 

  • Ross SB, Renyi AL (1977) Inhibition of the neuronal uptake of 5-hydroxy-tryptamine and nor-adrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3(3-pyridyl)-allyl- amines and their secondary analogues. Neuropharmacology 16: 57–63

    Article  PubMed  CAS  Google Scholar 

  • Wagner A (1980 a) On the molecular structure of some psychoactive drugs. Studies of the antidepressant alaproclate and two potentially neuroleptic rigid spiro amines. Thesis. Chem Commun 5: 1–61

    Google Scholar 

  • Wagner A (1980 b) Structure and absolute configuration of (R)-alaproclate[2-(4-chlorophenyl)- 1,1 -dimethyl-2-amino propanoate] hydrochloride, a selective inhibitor of neuronal 5-hy- droxytryptamine uptake. Acta Cryst B36:77–81

    Google Scholar 

  • Wagner A (1980 c) Crystal structure and absolute configuration of the hydrochloride of a dopamine receptor blocking rigid spiro amine: (lS,4R)-3′-cMoro-N,N-dimethyl spiro [2-cyclo- hexene-1,5′-[5H]dibenzo(a,d)cyclohepten]4-amine. Acta Crystallogr Sect B:1113—1117

    Google Scholar 

  • Wagner A, Ekqvist B, Bertilsson L, Sjôqvist F (1984) Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic receptors. Life Sci 35: 1379–1383

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Wagner, A., Fork, P. (1987). Molecular Approach to the Mechanism of Action of Antidepressant Drugs. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71288-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71290-6

  • Online ISBN: 978-3-642-71288-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics