Neuroleptic-Induced Parkinsonism Increases with Repeated Treatment in Monkeys
Neuroleptic-induced extrapyramidal symptoms (dystonia, parkinsonism, and akathisia) are frequent side effect problems in managing acute psychosis. The prevalence of these neurological syndromes varies widely from 2.2%–95% (Sovner and DiMascio 1978). This broad range is undoubtedly influenced by multiple variables, including patient characteristics (age, sex, previous extrapyramidal symptoms), drug parameters (dose, milligram-potency), and temporal aspects (early, intermediate, late) (Keepers et al. 1983; Casey and Keepers 1985; Keepers and Casey 1985). For example, low-milligram high-potency neuroleptics produce more extrapyramidal symptoms than high-milligram low-potency drugs. Drug dosage is also a factor which correlates positively with symptom prevalence and severity. However, even when these factors are kept constant, some patients may develop symptoms while others do not. These differences are currently attributed to variations in individual vulnerability.
KeywordsDopamine Morphine Acetylcholine Haloperidol Dystonia
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