Pharmacological Specificity Is Not the Same as Clinical Selectivity
Numerous putative antidepressants are currently being developed on the basis of selective theories of action. Most such theories are derived from experiments in animal pharmacology and extrapolated to the ill human condition. These selective theories continue to be promoted despite the fact that currently available so-called selective antidepressants appear to have comparable levels of efficacy with each other and with the nonselective antidepressants. The long delay between production of compounds and the testing of their clinical efficacy in depressed patients might allow some to think that time-honoured theories could be accepted without proper testing in the clinic.
KeywordsPlacebo Depression Noradrenaline Monoamine 5HIAA
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- Montgomery SA, Roy DH, Montgomery DB (1984) HVA: a marker for suicidal acts? Prog Neuropsychopharmacol 8: 159–166Google Scholar
- Sulser F (1984) Antidepressant treatments and regulation of norepinephrine - receptor-coupled adenylate cyclase systems in brain. Front Biochem Pharmacol Res Depression 39: 249–261Google Scholar