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Synthesis of New Peptides Based on Models of Receptor-Bound Conformation

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Clinical Pharmacology in Psychiatry

Abstract

About three dozen small peptides (mostly 2–40 residues) have been identified in the nervous system (Iversen 1983,1984; Krieger 1983). The neuropeptides mediate a wide range of endocrine, motor, and behavioral responses (Snyder 1980; Krieger 1983). These substances control such diverse functions as growth, reproduction, digestion, metabolism, and the dynamics of the cardiovascular system. Immunostaining techniques have been used to visualize and map the distribution of peptides, in particular neuronal pathways. Many of these substances have also been shown to occur in peripheral regions, such as the gastrointestinal tract. The role of many of these agents is largely unknown, but their potential utility in therapy is great.

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© 1987 Springer-Verlag Berlin Heidelberg

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Freidinger, R.M. et al. (1987). Synthesis of New Peptides Based on Models of Receptor-Bound Conformation. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-71288-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71290-6

  • Online ISBN: 978-3-642-71288-3

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