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Antidepressant Monoamine Oxidase Inhibitors Enhance Serotonin but not Norepinephrine Neurotransmission

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Clinical Pharmacology in Psychiatry

Part of the book series: Psychopharmacology Series ((PSYCHOPHARM,volume 3))

Abstract

Monoamine oxidase inhibitors (MAOIs) were the first effective drugs in the treatment of major depression (Klein et al. 1980). Given their inhibiting action on the catabolism of monoaminergic neurotransmitters, they constitute unique tools for investigating the neurobiological basis of the antidepressant response.

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Author information

Authors and Affiliations

  1. Centre de Recherche en Sciences Neurologiques, Faculté de Medecine, Université de Montreal, C.P. 6128, Succursale A, Montreal, H3C 3J7, Quebec, Canada

    P. Blier & C. de Montigny

Authors
  1. P. Blier
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  2. C. de Montigny
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, N-9001, Tromsø, Norway

    Svein G. Dahl Cand Real, Dr. Philos. (Professor of Pharmacology) (Professor of Pharmacology)

  2. Department of Clinical Pharmacology, School of Medicine, Odense University, DK-5000, Odense C, Denmark

    Lars F. Gram MD (Professor of Clinical Pharmacology) (Professor of Clinical Pharmacology)

  3. Clinical Neuroscience Branch, National Institute of Mental Health, Building 10, Room 4N214, 20205, Bethesda, MD, USA

    Steven M. Paul MD (Chief) (Chief)

  4. Section on Clinical Psychopharmacology, Laboratory of Clinical Science, Building 10, National Institute of Mental Health, 20205, Bethesda, MD, USA

    William Z. Potter MD, PhD (Chief) (Chief)

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© 1987 Springer-Verlag Berlin Heidelberg

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Blier, P., de Montigny, C. (1987). Antidepressant Monoamine Oxidase Inhibitors Enhance Serotonin but not Norepinephrine Neurotransmission. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_15

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  • DOI: https://doi.org/10.1007/978-3-642-71288-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71290-6

  • Online ISBN: 978-3-642-71288-3

  • eBook Packages: Springer Book Archive

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