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Regulation of Beta Adrenergic and Serotonin-S2 Receptors in Brain by Electroconvulsive Shock and Serotonin

  • Conference paper
Clinical Pharmacology in Psychiatry

Part of the book series: Psychopharmacology Series ((PSYCHOPHARM,volume 3))

  • 88 Accesses

Abstract

Two of the most consistent changes in brain that have been found following repeated administration of antidepressant drugs are decreases in the numbers of beta adrenergic receptors (Banerjee et al. 1977; Wolfe et al. 1978; Sarai et al. 1978; Bergstrom and Kellar 1979 a) and decreases in the number of serotonin-S2 (5-HT-2) receptors (Peroutka and Snyder 1980; Kellar et al. 1981 a). The decrease in the density of beta adrenergic receptors is associated with a decrease in the receptor- mediated production of cAMP (Vetulani and Sulser 1975; Vetulani et al. 1976). The functional consequences of the decrease in serotonin-S2 receptor density is less clear at this time. These receptors appear to mediate serotonin-stimulated phosphatidylinositol hydrolysis (Conn and Sanders-Bush 1984), but the effect of antidepressant drug treatment on this response is just beginning to be explored (Kendall and Nahorski 1985). The decrease in serotonin-S2 receptors may be linked to decreases in serotonin-mediated behavioral responses, but the high affinity of most of the antidepressants tested for the serotonin-S2-binding site in vitro and the possibility that the drugs block these receptors clouds this issue.

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Authors and Affiliations

  1. Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry, Washington, DC, 20007, USA

    K. J. Kellar, C. A. Stockmeier & A. M. Martino

Authors
  1. K. J. Kellar
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  2. C. A. Stockmeier
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  3. A. M. Martino
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, N-9001, Tromsø, Norway

    Svein G. Dahl Cand Real, Dr. Philos. (Professor of Pharmacology) (Professor of Pharmacology)

  2. Department of Clinical Pharmacology, School of Medicine, Odense University, DK-5000, Odense C, Denmark

    Lars F. Gram MD (Professor of Clinical Pharmacology) (Professor of Clinical Pharmacology)

  3. Clinical Neuroscience Branch, National Institute of Mental Health, Building 10, Room 4N214, 20205, Bethesda, MD, USA

    Steven M. Paul MD (Chief) (Chief)

  4. Section on Clinical Psychopharmacology, Laboratory of Clinical Science, Building 10, National Institute of Mental Health, 20205, Bethesda, MD, USA

    William Z. Potter MD, PhD (Chief) (Chief)

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© 1987 Springer-Verlag Berlin Heidelberg

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Kellar, K.J., Stockmeier, C.A., Martino, A.M. (1987). Regulation of Beta Adrenergic and Serotonin-S2 Receptors in Brain by Electroconvulsive Shock and Serotonin. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-71288-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71290-6

  • Online ISBN: 978-3-642-71288-3

  • eBook Packages: Springer Book Archive

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