Advertisement

ZAK Zürich pp 218-223 | Cite as

Neuere Aspekte der Hämostase, Hämatologie und Hämorheologie bei der schweren EPH-Gestose

  • H. Graeff
  • R. von Hugo
  • R. Schröck
Conference paper
  • 16 Downloads
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 189)

Zusammenfassung

Das Syndrom der EPH-Gestose beinhaltet in außergewöhnlicher Weise eine Reihe von Veränderungen, die sowohl die Mutter als auch die utero-feto-plazentare Einheit, und damit das Kind, betreffen. Die schwere Form der EPH-Gestose und der Eklampsie ist immer noch eine der häufigsten mütterlicher Todesfälle und steht nach der Frühgeburtlichkeit an 2. Stelle der perinatalen Morbidität und Mortalität.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Atlas M, Barkai G, Menczer J, Houlou N, Liebermann P (1982) Thrombotic thrombocytopenic purpura in pregnancy. Br J Obstet Gynaecol 89:476–479PubMedCrossRefGoogle Scholar
  2. 2.
    Aznar J, Gilabert J, Estelles A, Fernandez MA, Villa P, Aznar JA (1982) Evaluation of the soluble fibrin monomer complexes and other coagulation parameters in obstetric patients. Thromb Res 27: 691–701PubMedCrossRefGoogle Scholar
  3. 3.
    Blombäck B, Hessel B, Hogg D, Therkildsen L (1978) A two-step fibrinogen-fibrin transition in blood coagulation. Nature 275:501–504PubMedCrossRefGoogle Scholar
  4. 4.
    Bodzenta A, Thromson JM, Poller L (1980) Prostacyclin activity in amniotic fluid in pre-eclampsia. Lancet 11:650CrossRefGoogle Scholar
  5. 5.
    Bonnar J, McNicol GP, Douglas AS (1971) Coagulation and fibrinolytic systems in pre-eclampsia and eclampsia. Br Med J 11:12–16CrossRefGoogle Scholar
  6. 6.
    Bussolino F, Benedetto C, Massobrio M, Canussi G (1980) Maternal vascular prostacyclin activity in preeclampsia. Lancet 11:702CrossRefGoogle Scholar
  7. 7.
    Chen YC, McLeod B, Hall ER, Wu KK (1981) Accelerated prostacyclin degradation in thrombotic thrombocytopenic purpura. Lancet 11:267–269CrossRefGoogle Scholar
  8. 8.
    Dadak C (1983) Anwendung von Prostazyklin und Thromboxan in Geburtshilfe und Gynäkologie. MMW 125:655–658Google Scholar
  9. 9.
    Dadak C, Kefalides A, Sinzinger H (1983) Hemostatic regulation via prostaglandins in gestosis. In: Janisch H, Reinold E (eds) Dilemmas in gestosis. Int. Symposium Vienna. Thieme, Thieme-Stratton, Stuttgart New York, pp 60–62Google Scholar
  10. 10.
    Diekmann WJ (1936) Blood and plasma volume changes in eclampsia. Am J Obstet Gynecol 32: 927–936Google Scholar
  11. 11.
    Dintenfass L (1982) On changes in aggregation of red cells, blood viscosity and plasma viscosity during normal gestation. Clin Hemorheol 2:175–188Google Scholar
  12. 12.
    Ebert CH, Beller FK (1979) High molecular weight fibrin derivatives in pre-eclampsia. In: Serneri GGN, Prentice CRM (eds) Haemostasis and thrombosis. Proceedings of the Serono Symposia, vol 15. Academic, London New York, pp 625–630Google Scholar
  13. 13.
    Edgar W, Millop C, Howie PW (1977) Composition of soluble fibrin complexes in pre-eclampsia. Thromb Res 10:567–574PubMedCrossRefGoogle Scholar
  14. 14.
    Gollwitzer R, Hafter R, Timpl R, Graeff H (1977) Immunological assay for a carboxyterminal peptide of the fibrinogen Aa-chain in normal and pathological sera. Thromb Res 11:859–868PubMedCrossRefGoogle Scholar
  15. 15.
    Graeff H, Hafter R (1982) Detection and relevance of crosslinked fibrin derivatives in blood. Semin Thromb Hemost 8:57–68PubMedCrossRefGoogle Scholar
  16. 16.
    Graeff H, Kuhn W (1980) Coagulation disorders in obstetrics. Thieme Stuttgart New York, Saunders, Philadelphia London TorontoGoogle Scholar
  17. 17.
    Graeff H, Hafter R, Bachmann L (1979) Subunit and macromolecular structure of circulating fibrin from obstetric patients with intravascular coagulation. Thromb Res 16:313–328PubMedCrossRefGoogle Scholar
  18. 18.
    Hafter R, Graeff H (1976) Estimation of soluble fibrin monomer complexes by agarose gel filtration. In: Davidson JF, Samama MM, Desnoyers PC (eds) Raven, New York, pp 137–149Google Scholar
  19. 19.
    Heilmann L, Ludwig H (1980) Die gestörte Mikrozirkulation bei der Gestose. Z Geburtshilfe Perinatol 184:187–194PubMedGoogle Scholar
  20. 20.
    Heilmann L, Siekmann U (1981) Die gestörte Mikrozirkulation bei der Gestose und der maternofetale Sauerstoffaustausch. Arch Gynakol 232:77–78Google Scholar
  21. 21.
    Howie PW, Prentice CRW, Forbes CD (1975) Failure of heparin therapy to affect the clinical course of severe pre-eclampsia. J Obstet Gynaecol Br Commonw 82:711–717CrossRefGoogle Scholar
  22. 22.
    Kaibara M, Marumoto Y, Taniguchi I, Kobayashi T (1982) Blood viscosity at a low shear rate in normal and abnormal pregnancies. Clin Hemorheol 2:209–217Google Scholar
  23. 23.
    Lewis PJ, Boylan P, Friedman LA, Hensby CN, Downing I (1980) Prostacyclin in pregnancy. Br Med J 280:1581–1582PubMedCrossRefGoogle Scholar
  24. 24.
    McMay DG (1965) Disseminated intravascular coagulation. An intermediary mechanism of disease. Harper & Row, New YorkGoogle Scholar
  25. 25.
    McMillop C, Howie PW, Forbes CD (1976) Soluble fibrinogen/fibrin complexes in pre-eclampsia. Lancet 1:56–58CrossRefGoogle Scholar
  26. 26.
    Mendling W (1983) Präeklampsie mit hämolytischer Anämie, Thrombocytopenie, Leber- und Nierenbeteiligung - eine ungewöhnliche Form der schweren Gestose. Geburtshilfe Frauenheilkd 43: 332–335PubMedCrossRefGoogle Scholar
  27. 27.
    Ozanne P, Miller FC, Meiselman HJ (1983) RBC aggregation in diabetic and pre-eclamptic pregnancy. Clin Hemorheol 1:145–154Google Scholar
  28. 28.
    Perkins RP (1979) Thrombocytopenia in obstetric syndromes. A review. Obstet Gynecol Surv 34: 101–114PubMedCrossRefGoogle Scholar
  29. 29.
    Pritchard JA, Weisman R Jr, Ratnoff OD, Visbourgh G (1954) Intravascular hemolysis. Thrombocytopenia and other hematologic abnormities associated with severe toxemia of pregnancy. N Engl J Med 250:89–98PubMedCrossRefGoogle Scholar
  30. 30.
    Pritchard JA, Cunningham FG, Mason RA (1976) Coagulation changes in eclampsia: Their frequency and pathogenesis. Am J Obstet Gynecol 124:855–859PubMedGoogle Scholar
  31. 31.
    Redman CWG, Denson KWE, Beilin LJ (1977) Factor VIII consumption in pre-eclampsia. Lancet II: 1249–1252Google Scholar
  32. 32.
    Remuzzi G, Rossi EC, Misiani R, Marchesi D, Mecca G, de Gaetano G, Donati MB (1980) Prostacyclin and thrombotic microangiopathy. Semin Thromb Hemostas 6:391–394CrossRefGoogle Scholar
  33. 33.
    Sagen N, Koller O, Haram K (1982) Haemoconcentration in severe pre-eclampsia. Br J Obstet Gynaecol 89:802–805PubMedCrossRefGoogle Scholar
  34. 34.
    Schmid-Schönbein H, Hugo R von, Rieger H (1976) Fließeigenschaften und Fließbedingungen bei gesteigerter Erythrozytenaggregation und Hyperkoagulabilität. In: Ludwig H, Kurz E (Hrsg) Ergebnisse der Angiologie, Bd 14: Die Beckenvenen. Schattauer, Stuttgart, S 205–221Google Scholar
  35. 35.
    Schröck R (1983) Hemodilution in gestosis: Indications - limitations. In: Janisch H, Reinold E (eds) Dilemmas in gestosis. Int. Symposium Vienna. Thieme, Thieme-Stratton, Stuttgart New York, pp 153–156Google Scholar
  36. 36.
    Schröck R, Heimisch W, Gebhard K, Mendler N (1981) Hyperonkotische Hämodilution beim schwangeren Schaf als Therapiemodell der EPH-Gestose. Z Geburtshilfe Perinatol 185:168–177PubMedGoogle Scholar
  37. 37.
    Siekmann U, Oggolter-Siekmann H, Heilmann L (1983) Prognostic value of raised red cell aggregation for the development of pregnancy-induced hypertension (PIH) (Abstr). Biorheology 3:271Google Scholar
  38. 38.
    Stuart MJ, Clark DA, Sunderji SG, Allen JB, Yambo T, Elrad H, Slott JH (1981) Decreased prostacyclin production: A characteristic of chronic placental insufficiency syndromes. Lancet 1:1126–1128PubMedCrossRefGoogle Scholar
  39. 39.
    Sunder-Plassman L, Klövekorn WP, Holter K, Hase U, Messmer K (1971) The physiological significance of acutely induced hemodilution. Proc. 6th Eur. Conf. Microcir., Aalborg 1970. Karger, Basel, pp 23–31Google Scholar
  40. 40.
    Vane JR, Bunting S, Moncada S (1982) Prostacyclin in physiology and pathophysiology. Int Rev Exp Pathol 23:162–207Google Scholar
  41. 41.
    Weitz S, Borok Z, Owen J, Auerbach M, Nossel HL (1983) Fibrin proteolysis and platelet a-granule release in pre-eclampsia and eclampsia (Abstr). Thromb Haemost 50:322Google Scholar
  42. 42.
    Wengeler H, Holzgreve H, Gokel JM, Holzmann K (1976) Thrombotisch-thrombozytopenische Purpura (Moschkowitz-Syndrom) in der Schwangerschaft. Geburtshilfe Frauenheilkd 36:953–959PubMedGoogle Scholar
  43. 43.
    Ylikorkala O (1983) Prostacyclin and thromboxane during human pregnancy. Acta Obstet Gynecol Scand [Suppl] 113:51–53CrossRefGoogle Scholar
  44. 44.
    Ylikorkala O, Kirkinen P, Viinikka L (1981) Maternal plasma prostacyclin concentration in preeclampsia and other pregnancy complications. Br J Obstet Gynaecol 88:968–972PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. Graeff
  • R. von Hugo
  • R. Schröck

There are no affiliations available

Personalised recommendations