Skip to main content

Neuere Aspekte der Hämostase, Hämatologie und Hämorheologie bei der schweren EPH-Gestose

  • Conference paper
ZAK Zürich

Zusammenfassung

Das Syndrom der EPH-Gestose beinhaltet in außergewöhnlicher Weise eine Reihe von Veränderungen, die sowohl die Mutter als auch die utero-feto-plazentare Einheit, und damit das Kind, betreffen. Die schwere Form der EPH-Gestose und der Eklampsie ist immer noch eine der häufigsten mütterlicher Todesfälle und steht nach der Frühgeburtlichkeit an 2. Stelle der perinatalen Morbidität und Mortalität.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Atlas M, Barkai G, Menczer J, Houlou N, Liebermann P (1982) Thrombotic thrombocytopenic purpura in pregnancy. Br J Obstet Gynaecol 89:476–479

    Article  PubMed  CAS  Google Scholar 

  2. Aznar J, Gilabert J, Estelles A, Fernandez MA, Villa P, Aznar JA (1982) Evaluation of the soluble fibrin monomer complexes and other coagulation parameters in obstetric patients. Thromb Res 27: 691–701

    Article  PubMed  CAS  Google Scholar 

  3. Blombäck B, Hessel B, Hogg D, Therkildsen L (1978) A two-step fibrinogen-fibrin transition in blood coagulation. Nature 275:501–504

    Article  PubMed  Google Scholar 

  4. Bodzenta A, Thromson JM, Poller L (1980) Prostacyclin activity in amniotic fluid in pre-eclampsia. Lancet 11:650

    Article  Google Scholar 

  5. Bonnar J, McNicol GP, Douglas AS (1971) Coagulation and fibrinolytic systems in pre-eclampsia and eclampsia. Br Med J 11:12–16

    Article  Google Scholar 

  6. Bussolino F, Benedetto C, Massobrio M, Canussi G (1980) Maternal vascular prostacyclin activity in preeclampsia. Lancet 11:702

    Article  Google Scholar 

  7. Chen YC, McLeod B, Hall ER, Wu KK (1981) Accelerated prostacyclin degradation in thrombotic thrombocytopenic purpura. Lancet 11:267–269

    Article  Google Scholar 

  8. Dadak C (1983) Anwendung von Prostazyklin und Thromboxan in Geburtshilfe und Gynäkologie. MMW 125:655–658

    CAS  Google Scholar 

  9. Dadak C, Kefalides A, Sinzinger H (1983) Hemostatic regulation via prostaglandins in gestosis. In: Janisch H, Reinold E (eds) Dilemmas in gestosis. Int. Symposium Vienna. Thieme, Thieme-Stratton, Stuttgart New York, pp 60–62

    Google Scholar 

  10. Diekmann WJ (1936) Blood and plasma volume changes in eclampsia. Am J Obstet Gynecol 32: 927–936

    Google Scholar 

  11. Dintenfass L (1982) On changes in aggregation of red cells, blood viscosity and plasma viscosity during normal gestation. Clin Hemorheol 2:175–188

    Google Scholar 

  12. Ebert CH, Beller FK (1979) High molecular weight fibrin derivatives in pre-eclampsia. In: Serneri GGN, Prentice CRM (eds) Haemostasis and thrombosis. Proceedings of the Serono Symposia, vol 15. Academic, London New York, pp 625–630

    Google Scholar 

  13. Edgar W, Millop C, Howie PW (1977) Composition of soluble fibrin complexes in pre-eclampsia. Thromb Res 10:567–574

    Article  PubMed  CAS  Google Scholar 

  14. Gollwitzer R, Hafter R, Timpl R, Graeff H (1977) Immunological assay for a carboxyterminal peptide of the fibrinogen Aa-chain in normal and pathological sera. Thromb Res 11:859–868

    Article  PubMed  CAS  Google Scholar 

  15. Graeff H, Hafter R (1982) Detection and relevance of crosslinked fibrin derivatives in blood. Semin Thromb Hemost 8:57–68

    Article  PubMed  CAS  Google Scholar 

  16. Graeff H, Kuhn W (1980) Coagulation disorders in obstetrics. Thieme Stuttgart New York, Saunders, Philadelphia London Toronto

    Google Scholar 

  17. Graeff H, Hafter R, Bachmann L (1979) Subunit and macromolecular structure of circulating fibrin from obstetric patients with intravascular coagulation. Thromb Res 16:313–328

    Article  PubMed  CAS  Google Scholar 

  18. Hafter R, Graeff H (1976) Estimation of soluble fibrin monomer complexes by agarose gel filtration. In: Davidson JF, Samama MM, Desnoyers PC (eds) Raven, New York, pp 137–149

    Google Scholar 

  19. Heilmann L, Ludwig H (1980) Die gestörte Mikrozirkulation bei der Gestose. Z Geburtshilfe Perinatol 184:187–194

    PubMed  CAS  Google Scholar 

  20. Heilmann L, Siekmann U (1981) Die gestörte Mikrozirkulation bei der Gestose und der maternofetale Sauerstoffaustausch. Arch Gynakol 232:77–78

    Google Scholar 

  21. Howie PW, Prentice CRW, Forbes CD (1975) Failure of heparin therapy to affect the clinical course of severe pre-eclampsia. J Obstet Gynaecol Br Commonw 82:711–717

    Article  CAS  Google Scholar 

  22. Kaibara M, Marumoto Y, Taniguchi I, Kobayashi T (1982) Blood viscosity at a low shear rate in normal and abnormal pregnancies. Clin Hemorheol 2:209–217

    Google Scholar 

  23. Lewis PJ, Boylan P, Friedman LA, Hensby CN, Downing I (1980) Prostacyclin in pregnancy. Br Med J 280:1581–1582

    Article  PubMed  CAS  Google Scholar 

  24. McMay DG (1965) Disseminated intravascular coagulation. An intermediary mechanism of disease. Harper & Row, New York

    Google Scholar 

  25. McMillop C, Howie PW, Forbes CD (1976) Soluble fibrinogen/fibrin complexes in pre-eclampsia. Lancet 1:56–58

    Article  Google Scholar 

  26. Mendling W (1983) Präeklampsie mit hämolytischer Anämie, Thrombocytopenie, Leber- und Nierenbeteiligung - eine ungewöhnliche Form der schweren Gestose. Geburtshilfe Frauenheilkd 43: 332–335

    Article  PubMed  CAS  Google Scholar 

  27. Ozanne P, Miller FC, Meiselman HJ (1983) RBC aggregation in diabetic and pre-eclamptic pregnancy. Clin Hemorheol 1:145–154

    Google Scholar 

  28. Perkins RP (1979) Thrombocytopenia in obstetric syndromes. A review. Obstet Gynecol Surv 34: 101–114

    Article  PubMed  CAS  Google Scholar 

  29. Pritchard JA, Weisman R Jr, Ratnoff OD, Visbourgh G (1954) Intravascular hemolysis. Thrombocytopenia and other hematologic abnormities associated with severe toxemia of pregnancy. N Engl J Med 250:89–98

    Article  PubMed  CAS  Google Scholar 

  30. Pritchard JA, Cunningham FG, Mason RA (1976) Coagulation changes in eclampsia: Their frequency and pathogenesis. Am J Obstet Gynecol 124:855–859

    PubMed  CAS  Google Scholar 

  31. Redman CWG, Denson KWE, Beilin LJ (1977) Factor VIII consumption in pre-eclampsia. Lancet II: 1249–1252

    Google Scholar 

  32. Remuzzi G, Rossi EC, Misiani R, Marchesi D, Mecca G, de Gaetano G, Donati MB (1980) Prostacyclin and thrombotic microangiopathy. Semin Thromb Hemostas 6:391–394

    Article  CAS  Google Scholar 

  33. Sagen N, Koller O, Haram K (1982) Haemoconcentration in severe pre-eclampsia. Br J Obstet Gynaecol 89:802–805

    Article  PubMed  CAS  Google Scholar 

  34. Schmid-Schönbein H, Hugo R von, Rieger H (1976) Fließeigenschaften und Fließbedingungen bei gesteigerter Erythrozytenaggregation und Hyperkoagulabilität. In: Ludwig H, Kurz E (Hrsg) Ergebnisse der Angiologie, Bd 14: Die Beckenvenen. Schattauer, Stuttgart, S 205–221

    Google Scholar 

  35. Schröck R (1983) Hemodilution in gestosis: Indications - limitations. In: Janisch H, Reinold E (eds) Dilemmas in gestosis. Int. Symposium Vienna. Thieme, Thieme-Stratton, Stuttgart New York, pp 153–156

    Google Scholar 

  36. Schröck R, Heimisch W, Gebhard K, Mendler N (1981) Hyperonkotische Hämodilution beim schwangeren Schaf als Therapiemodell der EPH-Gestose. Z Geburtshilfe Perinatol 185:168–177

    PubMed  Google Scholar 

  37. Siekmann U, Oggolter-Siekmann H, Heilmann L (1983) Prognostic value of raised red cell aggregation for the development of pregnancy-induced hypertension (PIH) (Abstr). Biorheology 3:271

    Google Scholar 

  38. Stuart MJ, Clark DA, Sunderji SG, Allen JB, Yambo T, Elrad H, Slott JH (1981) Decreased prostacyclin production: A characteristic of chronic placental insufficiency syndromes. Lancet 1:1126–1128

    Article  PubMed  CAS  Google Scholar 

  39. Sunder-Plassman L, Klövekorn WP, Holter K, Hase U, Messmer K (1971) The physiological significance of acutely induced hemodilution. Proc. 6th Eur. Conf. Microcir., Aalborg 1970. Karger, Basel, pp 23–31

    Google Scholar 

  40. Vane JR, Bunting S, Moncada S (1982) Prostacyclin in physiology and pathophysiology. Int Rev Exp Pathol 23:162–207

    Google Scholar 

  41. Weitz S, Borok Z, Owen J, Auerbach M, Nossel HL (1983) Fibrin proteolysis and platelet a-granule release in pre-eclampsia and eclampsia (Abstr). Thromb Haemost 50:322

    Google Scholar 

  42. Wengeler H, Holzgreve H, Gokel JM, Holzmann K (1976) Thrombotisch-thrombozytopenische Purpura (Moschkowitz-Syndrom) in der Schwangerschaft. Geburtshilfe Frauenheilkd 36:953–959

    PubMed  CAS  Google Scholar 

  43. Ylikorkala O (1983) Prostacyclin and thromboxane during human pregnancy. Acta Obstet Gynecol Scand [Suppl] 113:51–53

    Article  CAS  Google Scholar 

  44. Ylikorkala O, Kirkinen P, Viinikka L (1981) Maternal plasma prostacyclin concentration in preeclampsia and other pregnancy complications. Br J Obstet Gynaecol 88:968–972

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Graeff, H., von Hugo, R., Schröck, R. (1986). Neuere Aspekte der Hämostase, Hämatologie und Hämorheologie bei der schweren EPH-Gestose. In: Hossli, G., Frey, P., Kreienbühl, G. (eds) ZAK Zürich. Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, vol 189. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71270-8_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71270-8_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16619-1

  • Online ISBN: 978-3-642-71270-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics