ZAK Zürich pp 188-195 | Cite as

Pharmacology of Antagonists of Neuromuscular Blocking Drugs

  • W. C. Bowman
Conference paper
Part of the Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine book series (A+I, volume 188)


Antagonists of nondepolarizing neuromuscular blocking drugs act by increasing the concentration of the transmitter acetylcholine in the junctional cleft of the neuromuscular junction, so that competition with the blocking drug is shifted in favor of the transmitter, thereby restoring transmission. The concentration of junctional acetylcholine may be increased in two main ways:
  1. 1.

    By inhibiting its breakdown with anticholinesterase drugs or

  2. 2.

    By increasing its evoked release from the nerve endings with drugs such as aminopyridines.



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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

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  • W. C. Bowman

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