Effects of Zineb on Hepatic Microsomal Systems in Rats and Mice
The effects of acute oral treatment with Zineb on hepatic microsomal xenobiotic metabolizing systems were studied in rats and mice. Administration of Zineb at doses from 200 to 600 mg/kg caused a significant impairment of aminopyrine-N-demethylase in the two species, as well as an inhibition of aniline hydroxylase in rats and a slight increase of this enzymatic activity in mice. The effects were absent at 2 h, reached maximum at 24 h and disappeared within 48 h after treatment. The cytochrome P-450 levels were not modified. The inhibitory and stimulatory effects of Zineb were discussed in relation to its metabolites such as ethylenethiourea and ethylenebisdithiocynato sulfide in these animal species.
Key wordsZineb Ethylenebisdithiocarbamate fungicides Mixed function oxidase Cytochrome P-450
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