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Cellular Defense Mechanisms Against Toxic Substances

  • Conference paper
Toxic Interfaces of Neurones, Smoke and Genes

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 9))

Abstract

Recent studies of cellular defense mechanisms against toxic substances are reviewed with particular emphasis on the critical functions of reduced glutathione. Studies of the metabolism of paracetamol and of the redox active quinone menadione in isolated rat hepatocytes, are summarized in order to illustrate how multiple defense mechanisms are involved in the protection of the cell against the toxicity of these agents. Cytotoxicity with both agents occurs only after the cellular defense mechanisms have become exhausted.

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Author information

Authors and Affiliations

  1. Department of Toxicology, Karolinska Institutet, S-10401, Stockholm, Sweden

    T. W. Jones, H. Thor & S. Orrenius

Authors
  1. T. W. Jones
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  2. H. Thor
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  3. S. Orrenius
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Claire M. Chambers  & Philip L. Chambers  & 

  2. Department of Environmental Hygiene and Toxicology, National Public Health Institute, P.O.B. 95, SF 70701, Kuopio, Finland

    Jouko Tuomisto

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© 1986 Springer-Verlag

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Jones, T.W., Thor, H., Orrenius, S. (1986). Cellular Defense Mechanisms Against Toxic Substances. In: Chambers, C.M., Chambers, P.L., Tuomisto, J. (eds) Toxic Interfaces of Neurones, Smoke and Genes. Archives of Toxicology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71248-7_41

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  • DOI: https://doi.org/10.1007/978-3-642-71248-7_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16589-7

  • Online ISBN: 978-3-642-71248-7

  • eBook Packages: Springer Book Archive

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