Chemotherapy of Childhood Brain Stem Tumors

  • M. K. Neidhardt
Conference paper


The majority of brain stem tumors occur in children (Bloom 1975), and in recent years considerable progress has been obtained with chemotherapy for most pediatric tumors (Mauer et al. 1977; Lampert 1982). It would therefore seem appropriate to have a pediatrician speak on chemotherapy of brain stem tumors.


Nitrogen Mustard Childhood Brain Tumor Brain Stem Tumor Brain Stem Glioma Methyl CCNU 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Albright AL, Price RA, Guthkelch AN (1983) Brain stem gliomas of children — a clinicopathological study. Cancer 52: 2313–2319PubMedCrossRefGoogle Scholar
  2. Allen JC, Helson L (1981) High-dose cyclophosphamide chemotherapy for recurrent CNS tumors in children. J Neurosurg 55: 749–756PubMedCrossRefGoogle Scholar
  3. Bloom HJG (1975) Tumours of the central nervous system. In: Bloom HJG, Lemerle J, Neidhardt MK, Voute PA (eds) Cancer in children — clinical management. Springer, Berlin Heidelberg New York, p 93–119Google Scholar
  4. Bloom HJG, Thornton H, Schweisguth O (1982) SIOP medulloblastoma and high grade ependymoma therapeutic clinical trial: preliminary results (1975–1981). In: Raybaud C, Clement R, Lebreuil G, Bernard JL (eds) Pediatric Oncology. Excerpta Medica, Amsterdam Oxford Princeton, p 309–322Google Scholar
  5. Bordigoni P, Brocard O, Bey P, Montaut J, Picard L, Olive D (1980) Les gliomes du tronc: aspects cliniques, therapeutiques et evolutifs. Med Hyg 38: 589–601Google Scholar
  6. Cangir A, Ragab AH, Steuber P, Land VJ, Berry DH, Krischer JP (1984) Combination chemotherapy with vincristine, procarbazine, prednisone with or without nitrogen mustard (MOPP vs OPP) in children with recurrent brain tumors. Med Pediatr Oncol 12: 1–3PubMedCrossRefGoogle Scholar
  7. Djerassi I, Kim JS, Shulman K (1977) High-dose methotrexate-citrovorum factor rescue in the management of brain tumors. Cancer Treat Rep 61: 691–694PubMedGoogle Scholar
  8. Edwards MS, Levin VA, Wilson CB (1980) Chemotherapy of pediatric posterior fossa tumors. Child’s Brain 7: 252–260PubMedGoogle Scholar
  9. Evans AE (1983) Therapeutic approaches to medulloblastoma and results: the trial of the Children’s Cancer Study Group (CCSG) and the Radiation Therapy Oncology Group (RTOG). Proceedings of the 13th International Congress of Chemotherapy, Vienna, Fascicle SY 101–106Google Scholar
  10. Fewer D, Wilson CB, Boldrey EB, Enot, JK (1972) Phase II study of CCNU in the treatment of brain tumors. Cancer Chemother Rep 56: 421–427PubMedGoogle Scholar
  11. Fulton DS, Levin VA, Wara WM, Edwards MS, Wilson CB (1981) Chemotherapy of pediatric brain stem tumors. J Neurosurg 54: 721–725PubMedCrossRefGoogle Scholar
  12. Gutjahr P, Voth D, Heidfeld J, Walther B, Kutzner J, Kretzschmar K (1982) Infratentorial tumors — treatment and results in 109 children. In: Voth D, Gutjahr P, Langmaid C ( eds) Tumors of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, p 358–364Google Scholar
  13. Khan AB, D’Souza BJ, Wharam MD, Champion LAA, Sinks LF, Woo SY, McCullough DC, Leventhal BG (1982) Cisplatin therapy in recurrent childhood brain tumors. Cancer Treat Rep 66: 2013–2020PubMedGoogle Scholar
  14. Kumar ARV, Renaudin J, Wilson CB, Boldrey EB, Enot KJ, Levin VA (1974) Procarbazine hydrochloride in the treatment of brain tumors. J Neurosurg 40: 365–371CrossRefGoogle Scholar
  15. Lampert F (1982) Childhood cancer studies in West Germany: the first 10 years. Klin Püdiatr 194: 195–203CrossRefGoogle Scholar
  16. Levin VA, Edwards MS, Wara WM, Allen J, Ortega J, Vestays P (1984) 5-Fluorouracil and CCNU followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Children’s Cancer Group. Neurosurgery 14: 679–681PubMedCrossRefGoogle Scholar
  17. Littman P, Jarrett P, Bilaniuk LT, Rorke LB, Zimmerman RA, Bruce DA, Carabell SC, Schut L (1980) Pediatric brain stem gliomas. Cancer 45: 2787–2792PubMedCrossRefGoogle Scholar
  18. Mauer AM, Simone N, Pratt CB (1977) Current progress in the treatment of the child with cancer. J Pediatr 91: 523–539PubMedCrossRefGoogle Scholar
  19. Mellet LB (1977) Physicochemical considerations and pharmacokinetic behavior ih delivery of drugs to the central nervous system. Cancer Treat Rep 61: 527–531Google Scholar
  20. Nagai M, Arai T, Kohno S, Kohase M (1980) Interferon therapy for malignant brain tumors. In: Kono R, Vilcek J (eds) The clinical potential of interferons. Proc Int Clin Pot Interferons; Jap Med Res Found Publ, No 15, p 257–273Google Scholar
  21. Newton WAjr, Sayers MP, Samuels LD (1968) Intrathecal methotrexate therapy for brain tumors in children. Cancer Chemother Rep 52: 257–261PubMedGoogle Scholar
  22. Olive D, Benz E, Philip T, Brunat-Mentigny M, Zucker JM, Vannier JP (1984) Efficacy of “8 drugs in I day” regimen in the treatment of childhood brain tumors. 16th meeting of the International Society of Paediatric Oncology, Barcelona (Abstract No. 50)Google Scholar
  23. Rall DP, Zubrod CG (1962) Mechanism of drug absorption and excretion. Passage of drugs in and out of the central nervous system. Ann Rev Pharmacol 2: 109–128CrossRefGoogle Scholar
  24. Reigel DH, Scarff TB, Woodford JE (1979) Biopsy of pediatric brain stem tumors. Child’s Brain 5: 329–340PubMedGoogle Scholar
  25. Rosen G, Ghavimi F, Nirenberg A, Mosende C, Mehta BM (1977) High-dose methotrexate with citrovorum factor rescue for the treatment of central nervous system tumors in children. Cancer Treat Rep 61: 681–690PubMedGoogle Scholar
  26. Rosenblum ML, Reynolds AF, Smith KA, Rumack BH, Walker MD (1973) Chlorethyl-cyclohexyl-nitrosourea (CCNU) in the treatment of brain tumors. J Neurosurg 39: 306–314PubMedCrossRefGoogle Scholar
  27. Schmitt HP, Zeisner W (1982) The diffuse brain stem astrocytoma in childhood: morphology, course, and prognosis. In: Voth D, Gutjahr P, Langmaid C (eds) Tumors of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, p 149–164Google Scholar
  28. Shapiro WR, Allen JC, Mehta B, Blasberg RG, Kobayshi T, Patlak CS (1979) Pharmacodynamics of entry of methotrexate into brain of humans, monkeys and a rat brain tumor model. In: Paoletti P, Walker MD, Butti G, Knerich R (eds) Multidisciplinary aspects of brain tumor therapy. Elsevier North Holland Biomedical Press, Amsterdam, p 135–142Google Scholar
  29. Sheline GE (1975) Radiation therapy of tumors of the central nervous system in childhood. Cancer 35: 957–964PubMedCrossRefGoogle Scholar
  30. Taylor SG, Nelson L, Baxter D, Rosenbaum C, Sponzo RW, Cunningham TJ, Olson KB, Horton J (1975) Treatment of grade III and IV astrocytoma with Dimethyl Triazeno Imidazole Carboxamide (DTIC) alone and in combination with CCNU or Methyl CCNU. Cancer 36: 1269–1276PubMedCrossRefGoogle Scholar
  31. Vick NA, Khandekar JD, Bigner DD (1977) Chemotherapy of brain tumors. The “blood-brain barrier” is not a factor. Arch Neurol 34: 523–526PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • M. K. Neidhardt
    • 1
  1. 1.AugsburgGermany

Personalised recommendations