Skip to main content

The Influence of Volatile Anesthetics on Cerebral Blood Flow and Cerebral Autoregulation

  • Conference paper
Inhalation Anesthetics
  • 75 Accesses

Abstract

The intracranial space, which is surrounded by cranial bone, can be divides into several compartments; in normal adults it consists of: 700–900 ml glia, 500–700 ml neurons, 100–150 ml blood (arterial and venous), 100–150 ml cerebrospinal fluid (CSF), and >75 ml extracellular fluid (ECF).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Artru AA, Nugent M, Michenfelder JD (1982) Enflurane causes a prolonged and reversible increase in the rate of CSF production in the dog. Anesthesiology 57: 255–260

    Article  PubMed  CAS  Google Scholar 

  2. Artru AA (1983) Effects of halothane and fentanyl on the rate of CSF production in dogs. Anesth Analg 62: 581–585

    Article  PubMed  CAS  Google Scholar 

  3. Marx GF, Andrews IC, Orkin LR (1982) Cerebrospinal fluid pressure during halothane anaesthesia. Ca. Anaesth Soc 9: 239–245

    Article  Google Scholar 

  4. McDonwall DG (1967) The effects of clinical concentrations of halothane on the blood flow and oxygen uptake of cerebral cortex. Br J Anaesth 39: 186–196

    Article  Google Scholar 

  5. Stullken EH, Milde JH, Michenfelder JD, Tinker JH (1977) The nonlinear response of cerebral metabolism to low concentrations of halothane, enflurane, isoflurane and thiopetol. Anesthesiology 46: 28–34

    Article  PubMed  CAS  Google Scholar 

  6. Albrecht RF, Miletich DJ, Rosenberg R, Zahed B (1977) Cerebral blood flow and metabolic changes from induction to onset of anesthesia with halothane or pentobarbital. Anesthesiology 47: 252–256

    Article  PubMed  CAS  Google Scholar 

  7. Steen PA (1982) Die Wirkung von Inhalationsanaesthetika auf das Gehirn. In: Peter K, Jesch F (eds) Inhalationsanaesthesie heute und morgen. Springer Berlin Heidelberg New York (Anaesthesiologie und Intensivmedizin, vol 149 )

    Google Scholar 

  8. Miletich DJ, Ivankovich AD, Albrecht RF, Reimann CR, Rosenberg R, McKissic ED (1976) Absence of autoregulation of cerebral blood flow during halothane and enflurane anesthesia. Anesth Analg 55: 100–109

    PubMed  CAS  Google Scholar 

  9. Misfeldt BB, Jörgensen PB, Rishöj M (1974) The effect of nitrous oxide and halothane upon the intracranial pressure in hypocapnic patients with intracranial disorders. Br J Anaesth 46: 853–858

    Article  PubMed  CAS  Google Scholar 

  10. Christensen MS, Hoedt-Rasmussen K, Lassen NA (1967) Cerebral vasodilatation by halothane anaesthesia in man and its potentiation by hypotension and hypercapnia. Br J Anaesth 39:927– 934

    Google Scholar 

  11. Adams RW, Gronert GA, Sundt TM, Michenfelder JD (1972) Halothane, hypocapnia and cerebrospinal fluid pressure in neurosurgery. Anesthesiology 37: 510–517

    Article  PubMed  CAS  Google Scholar 

  12. Michenfelder JD, Cucchiara RF (1974) Canine cerebral oxygen consumption during enflurane anesthesia and its modification during induced seizures. Anesthesiology 40: 575–580

    Article  PubMed  CAS  Google Scholar 

  13. Boop WC, Knight R (1978) Enflurane anesthesia and changes of intracranial pressure. J Neurosurg 48: 228–231

    Article  PubMed  CAS  Google Scholar 

  14. Cunitz G, Danhauser I, Gruß P (1976) Die Wirkung von Endlurane (EthraneR) im Vergleich zu Halothan auf den intracraniellen Druck. Anaesthesist 25: 323–330

    PubMed  CAS  Google Scholar 

  15. Wollman H, Schmith AL, Neigh JL (1969) Cerebral blood flow and oxygen consumption in man during electrocephalographic seizure patterns associated with ethrane anesthesia in cerebral blood flow. In: Brock M, Fieschi C, et al. (eds) Cerebral blood flow. Springer, Berlin Heideiber New York pp 246–248

    Google Scholar 

  16. Murphy FL, Kennell EM, Johnstone RE (1974) The effects of enflurane, isoflurane and halothane on cerebral blood flow and metabolism in man. Abstract of scientific papers, Annual meeting of the American Socienty of Anesthesiologist, pp 62–63

    Google Scholar 

  17. Adams RW, Cucchiara RF, Gronert GA, Messik JM, Michenfelder JD (1981) Isoflurane and cerebrospinal fluid pressure in neurosurgical patients. Anesthesiology 54: 97–99

    Article  PubMed  CAS  Google Scholar 

  18. Campkin TV (1984) Isoflurane and extradural pressure. A study in neurosurgical patients. Br J Anaesth 56: 1083–1087

    Article  PubMed  CAS  Google Scholar 

  19. Grosslight K, Colohain A, Bedford RF (1984) Isoflurane for neuroanesthesia risk factors for in-creases in ICP Abstract of the XII Annual Meeting of the Society of Neurosurgical Anesthesia and Neurologic Supportive Care, New Orleans pp 8–10

    Google Scholar 

  20. Newberg LA, Milde JH Michenfelder JD (1983) The cerebral metabolic effects of isoflurane at and above concentrations that suppress cortical electrical activity. Anesthesiology 59: 23–28

    Article  PubMed  CAS  Google Scholar 

  21. Newberg LA, Michenfelder JD (1983) Cerebral protection by isoflurane during hypoxemia or ischemia. Anesthesiology 59: 29–35

    Article  PubMed  CAS  Google Scholar 

  22. Lam AM, Geld AW (1983) Cardiovascular effects of isoflurane-induced hypotension for cerebral aneurysm surgery. Anesth Analg 62: 742–748

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Van Aken, H., Hauss, GM., Brüssel, T., Fitch, W. (1987). The Influence of Volatile Anesthetics on Cerebral Blood Flow and Cerebral Autoregulation. In: Peter, K., Brown, B.R., Martin, E., Norlander, O. (eds) Inhalation Anesthetics. Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, vol 185. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71232-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71232-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16575-0

  • Online ISBN: 978-3-642-71232-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics